122851-60-9

Basic information

• Product Name: 2-(3-bromopyridin-2-yl)acetonitrile
• Synonyms: 2-(3-bromopyridin-2-yl)acetonitrile;(3-BROMOPYRIDIN-2-YL)ACETONITRILE;3-BroMo-2-pyridineacetonitrile;3-Bromopyridine-2-acetonitrile
• CAS NO: 122851-60-9
• Molecular Formula: C₇H₅BrN₂
• Molecular Weight: 197.035
• Mol File: 122851-60-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 63-64 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 279.5°C at 760 mmHg
• Flash Point: 122.8°C
• Appearance: /
• Density: 1.575g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.82±0.22(Predicted)
• CAS DataBase Reference: 2-(3-bromopyridin-2-yl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromopyridin-2-yl)acetonitrile(122851-60-9)
• EPA Substance Registry System: 2-(3-bromopyridin-2-yl)acetonitrile(122851-60-9)

Safety Data

• Hazardous Substances Data: 122851-60-9(Hazardous Substances Data)

Usage

General Description

2-(3-bromopyridin-2-yl)acetonitrile is a chemical compound with the molecular formula C8H6BrN3. It is a nitrile derivative with a pyridine ring that contains a bromine atom at the 3-position. 2-(3-bromopyridin-2-yl)acetonitrile is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used as an intermediate in organic synthesis, particularly in the production of heterocyclic compounds. Additionally, 2-(3-bromopyridin-2-yl)acetonitrile can be utilized as a reagent in various chemical reactions and transformations. Due to its versatile nature, this compound has applications in both academic research and industrial processes.

InChI:InChI=1/C7H5BrN2/c8-6-2-1-5-10-7(6)3-4-9/h1-2,5H,3H2

Upstream product

• 13534-89-9 2,3-dibromopyridine 
• 75-05-8 acetonitrile 
• 36178-05-9 3-bromo-2-fluoropyridine 
• 773837-37-9 sodium cyanide 
• 754131-60-7 3-bromo-2-(bromomethyl)pyridine 
• 52378-64-0 3-bromo-2-hydroxymethyl-pyridine 
• 143-33-9 sodium cyanide 
• 38749-79-0 3-bromo-2-picoline 
• 122851-69-8 3-bromo-2-(chloromethyl)pyridine 

Downstream Products

• 910386-57-1 C₇H₉BrN₂ 
• 1616923-80-8 2-(3-phenylpyridin-2-yl)acetamidine acetic acid salt 
• 1404120-41-7 N-(4-(3-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenyl)pyrazolo[1,5-a]pyridin-2-yl)acetamide 
• 1616923-78-4 2-(3-phenylpyridin-2-yl)ethanimidamido acetate 
• 1616923-77-3 N-hydroxy-2-(3-phenylpyridin-2-yl)acetamidine 
• 1227494-24-7 (3-phenylpyridin-2-yl)acetonitrile 

Relevant articles and documents

TRIAZOLOPYRIDINE COMPOUNDS AND USES THEREOF

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R6, R7 and R8 are as defined herein.

Phenethyl nicotinamides, a novel class of NaV1.7 channel blockers: Structure and activity relationship

The NaV1.7 ion channel is an attractive target for development of potential analgesic drugs based on strong genetic links between mutations in the gene coding for the channel protein and inheritable pain conditions. The (S)-N-chroman-3-ylcarboxamide series, exemplified by 1, was used as a starting point for development of new channel blockers, resulting in the phenethyl nicotinamide series. The structure and activity relationship for this series was established and the metabolic issues of early analogues were addressed by appropriate substitutions. Compound 33 displayed acceptable overall in vitro properties and in vivo rat PK profile.

PYRIDINYL ACETONITRILES

The present invention is related to pyridinyl acetonitriles as well as to pharmaceutical formulations containing such pyridinyl acetonitriles. Said pyridinyl acetonitriles are modulators of the protein kinase signalling pathways, particularly the one involving Glycogen Kinase Synthase 3 or JNK. The present invention is furthermore related to methods of preparing pyridinyl acetonitriles. X is a substituted or unsubstituted pyridinyl. G is an unsubstituted or substituted pyrimidinyl or triazinyl.