1228547-99-6 Usage
General Description
(S)-2-O-tolylpiperidine is a chemical compound that belongs to the class of piperidine derivatives. It is a chiral compound, meaning it has a non-superimposable mirror image. (S)-2-O-TOLYLPIPERIDINE is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceuticals and other biologically active molecules. Its structure consists of a piperidine ring with a tolyl group attached to the second carbon atom, and its stereochemistry is defined by the (S) configuration, which indicates the absolute configuration of the asymmetric carbon atom in the molecule. (S)-2-O-tolylpiperidine has potential applications in drug discovery and development due to its versatile chemical reactivity and role as a precursor in the synthesis of pharmacologically active compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1228547-99-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,5,4 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1228547-99:
(9*1)+(8*2)+(7*2)+(6*8)+(5*5)+(4*4)+(3*7)+(2*9)+(1*9)=176
176 % 10 = 6
So 1228547-99-6 is a valid CAS Registry Number.
1228547-99-6Relevant articles and documents
Diversification of Unprotected Alicyclic Amines by C?H Bond Functionalization: Decarboxylative Alkylation of Transient Imines
Paul, Anirudra,Kim, Jae Hyun,Daniel, Scott D.,Seidel, Daniel
supporting information, p. 1625 - 1628 (2020/11/30)
Despite extensive efforts by many practitioners in the field, methods for the direct α-C?H bond functionalization of unprotected alicyclic amines remain rare. A new advance in this area utilizes N-lithiated alicyclic amines. These readily accessible intermediates are converted to transient imines through the action of a simple ketone oxidant, followed by alkylation with a β-ketoacid under mild conditions to provide valuable β-amino ketones with unprecedented ease. Regioselective α′-alkylation is achieved for substrates with existing α-substituents. The method is further applicable to the convenient one-pot synthesis of polycyclic dihydroquinolones through the incorporation of a SNAr step.
Efficient Routes to Chiral 2-Substituted and 2,6-Disubstituted Piperidines
Katritzky, Alan R.,Qiu, Guofang,Yang, Baozhen,Steel, Peter J.
, p. 6699 - 6703 (2007/10/03)
The syntheses of chiral 2-substituted and 2,6-disubstituted piperidines, and piperidin-2-ylphosphonates, via benzotriazole methodology are described.
