1228565-08-9

Upstream product

• 1228565-06-7 4-[2-(2-chloro-benzylamino)-pyrido[4,3-d]pyrimidin-5-yl]-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1228564-89-3 4-[2-(2-chloro-benzylamino)-pyrido[4,3-d]pyrimidin-5-yl]-piperazine-1-carboxylic acid pyridin-3-ylmethyl ester 
• 1228564-95-1 (2-chloro-benzyl)-[5-(4-methanesulfonyl-piperazin-1-yl)-pyrido[4,3-d]pyrimidin-2-yl]-amine 
• 1228564-72-4 1-(4-[2-(2-chloro-benzylamino)-pyrido[4,3-d]pyrimidin-5-yl]-piperazin-1-yl)-2-pyridin-4-yl-ethanone 
• 1228564-52-0 4-[2-(2-chloro-benzylamino)-pyrido[4,3-d]pyrimidin-5-yl]-piperazine-1-carboxylic acid (furan-2-ylmethyl)-amide 

Relevant academic research and scientific papers

2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER

The present invention relates to pyridopyrimidine derivatives according to formula (I), as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.