(2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride

Base Information

Chemical Name:(2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride
CAS No.:1228565-08-9
Molecular Formula:C₁₈H₁₉ClN₆*ClH
Molecular Weight:391.303
Hs Code.:

Synonyms:(2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride

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Chemical Property of (2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride

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Technology Process of (2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride

There total 1 articles about (2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1228565-06-7
4-[2-(2-chloro-benzylamino)-pyrido[4,3-d]pyrimidin-5-yl]-piperazine-1-carboxylic acid tert-butyl ester

: 1228565-08-9
(2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield: 92.0%

: 1228565-08-9
(2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride

: 124-63-0
methanesulfonyl chloride

: 1228564-95-1
(2-chloro-benzyl)-[5-(4-methanesulfonyl-piperazin-1-yl)-pyrido[4,3-d]pyrimidin-2-yl]-amine

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 6h;

Reference yield: 72.0%

: 100-55-0
3-hydroxymethylpyridin

: 1228565-08-9
(2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride

: 530-62-1
1,1'-carbonyldiimidazole

: 1228564-89-3
4-[2-(2-chloro-benzylamino)-pyrido[4,3-d]pyrimidin-5-yl]-piperazine-1-carboxylic acid pyridin-3-ylmethyl ester

Guidance literature:: 3-hydroxymethylpyridin; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 3h;

(2-chloro-benzyl)-(5-piperazin-1-yl-pyrido[4,3-d]pyrimidin-2-yl)-amine hydrochloride; In tetrahydrofuran; at 20 ℃; for 18h;