1228568-65-7 Usage
Uses
Used in Pharmaceutical Industry:
(2R)-2-(2-FLUOROPHENYL)PYRROLIDINE is used as a building block in the synthesis of pharmaceutical drugs, contributing to the development of new medications with enhanced efficacy and selectivity.
Used in Drug Development:
It serves as a pharmacophore in the development of new molecules with biological activity, aiding in the discovery of innovative treatments and therapies.
Used in Organic Synthesis:
(2R)-2-(2-FLUOROPHENYL)PYRROLIDINE is utilized in organic synthesis processes, enabling the creation of a variety of complex organic compounds for various applications.
Used as a Research Tool in Medicinal Chemistry:
It is employed as a research tool for understanding the structure-activity relationships of compounds in drug discovery, facilitating the advancement of knowledge in medicinal chemistry and the design of more effective drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 1228568-65-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,5,6 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1228568-65:
(9*1)+(8*2)+(7*2)+(6*8)+(5*5)+(4*6)+(3*8)+(2*6)+(1*5)=177
177 % 10 = 7
So 1228568-65-7 is a valid CAS Registry Number.
1228568-65-7Relevant academic research and scientific papers
Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases
Chen, Fei-Fei,Chen, Qi,Li, Bo-Bo,Xu, Jian-He,Zhang, Yu-Hui,Zheng, Gao-Wei,Zhou, Xin-Yi
supporting information, p. 3367 - 3372 (2020/04/21)
Exploring a collection of naturally occurring imine reductases (IREDs) identified two stereocomplementary IREDs with reducing activity toward sterically hindered 2-aryl-substituted pyrrolines. Using (R)-selective ScIR and (S)-selective SvIR, various chiral 2-aryl-substituted pyrrolidines with excellent enantioselectivity (>99% ee) were stereocomplementarily synthesized in good yield (60-80%), demonstrating the feasibility of IREDs for generating pharmaceutically relevant chiral 2-aryl-substituted pyrrolidine intermediates.
Transaminase reactions
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Page/Page column 96-97, (2018/12/11)
The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.
