1228573-54-3Relevant academic research and scientific papers
A quick synthesis of 1-arylpyrrolopyrazinones from linear alkynylamide derivatives
Pardo, Leticia M.,Tellitu, Imanol,Dominguez, Esther
experimental part, p. 971 - 978 (2010/05/18)
A rapid synthesis of pyrrolopyrazinone derivatives based on formal double addition across the triple bond of appropriately substituted substrates is presented. The key cyclization step features the formation, mediated by [bis(trifluoroacetoxy)iodo]benzene -(PIFA), of a 5-aroylpyrrolidinone nucleus from appropriately func-t-ionalized N-protected N-(aminoethyl)amides. After removal of the protecting group, the free amino group is used to accomplish a second heterocyclization process onto the newly formed carbonyl group. By appropriate manipulation of these protecting groups and selection of reaction conditions, a series of pyrrolopyrazinones can be obtained in different stages of hydrogenation. Georg Thieme Verlag Stuttgart · New York.
