1228595-65-0Relevant academic research and scientific papers
First biological evaluation of developed 3-benzyloxyfluorenes as novel class of MDR modulators
Krug, Martin,Voigt, Burkhardt,Baumert, Christiane,Lüpken, Ralf,Molnár, Joséf,Hilgeroth, Andreas
experimental part, p. 2683 - 2688 (2010/07/09)
A series of 3-benzyloxy-1-aza-9-oxafluorenes has been synthesized and biologically evaluated as novel MDR modulators. The concentration dependent inhibition of the efflux pump ABCB1 (P-glycoprotein) has been characterized and is discussed in relation to calculated lipophilicity data. Instead of the molecular lipophilicity the exact positioning of functional groups was found decisive for the biological activities.
