1228660-88-5

Basic information

• Product Name: cuprous 4-(trifluoromethyl)phenylacetylide
• Synonyms: cuprous 4-(trifluoromethyl)phenylacetylide
• CAS NO: 1228660-88-5
• Molecular Weight: 232.672
• Mol File: 1228660-88-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: cuprous 4-(trifluoromethyl)phenylacetylide(CAS DataBase Reference)
• NIST Chemistry Reference: cuprous 4-(trifluoromethyl)phenylacetylide(1228660-88-5)
• EPA Substance Registry System: cuprous 4-(trifluoromethyl)phenylacetylide(1228660-88-5)

Safety Data

• Hazardous Substances Data: 1228660-88-5(Hazardous Substances Data)

Upstream product

• 705-31-7 4-trifluoromethylphenylacetylene 
• 12775-96-1 copper 
• 7681-65-4 copper(l) iodide 

Downstream Products

• 1628218-91-6 ethyl 2,2-difluoro-4-(4-(trifluoromethyl)phenyl)but-3-ynoate 
• 1207324-42-2 4-amino-6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidine 
• 1206631-23-3 ethyl 5-(6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidin-4-ylaminomethyl)-2-furancarboxylate 

Relevant articles and documents

Electrochemical synthesis of copper(i) acetylides: Via simultaneous copper ion and catalytic base electrogeneration for use in click chemistry

We report an efficient and sustainable electrochemical synthesis of copper(i) acetylides using simultaneous copper oxidation and Hofmann elimination of quaternary ammonium salts. The electrochemically-generated base was also regenerated electrochemically,

Access to difluoromethylated alkynes through the castro-stephens reaction

An efficient synthesis of difluoromethylated alkynes is described. A panel of readily available CuI acetylides undergo direct difluoromethylation by using BrCF2CO2Et, which is an inexpensive, easy to handle, commercially available fluorinated reagent. The reaction, which is based on a Castro-Stephens transformation, proceeds smoothly under mild conditions offering a new synthetic route for the direct introduction of the difluoromethylated group into alkynes that does not involve ozone-depleting reagents. The resulting products were obtained with good yields by using CsOPiv and Cu(OAc)2 as additives.