1228671-28-0

Basic information

• Product Name: 4-((4-methoxypyrimidin-2-yl)amino)benzonitrile
• Synonyms: 4-((4-methoxypyrimidin-2-yl)amino)benzonitrile
• CAS NO: 1228671-28-0
• Molecular Weight: 226.238
• Mol File: 1228671-28-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-((4-methoxypyrimidin-2-yl)amino)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-methoxypyrimidin-2-yl)amino)benzonitrile(1228671-28-0)
• EPA Substance Registry System: 4-((4-methoxypyrimidin-2-yl)amino)benzonitrile(1228671-28-0)

Safety Data

• Hazardous Substances Data: 1228671-28-0(Hazardous Substances Data)

Upstream product

• 22536-63-6 2-chloro-4-methoxypyrimidine 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 244768-32-9 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile 
• 500287-72-9 rilpivirine 
• 189956-45-4 4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile 

Relevant articles and documents

Pyrimidine heterocyclic compounds, pyrimidine heterocyclic compound salts, and preparation method and application thereof

The invention provides pyrimidine heterocyclic compounds, pyrimidine heterocyclic compound salts, and a preparation method and application thereof. According to the pyrimidine heterocyclic compounds provided by the invention, specific Rq is selected, so that the obtained compounds have favorable drug resistance and long half life when being used as the medicine for treating or preventing HIV. The compounds have the advantages of high activity, low toxicity and high stability.

RILPIVIRINE HYDROCHLORIDE

The present invention provides a novel process for the preparation of rilpivirine. The present invention also provides a novel process for the preparation of rilpivirine hydrochloride. The present invention further provides a rilpivirine hydrochloride monohydrate, process for its preparation and pharmaceutical compositions comprising it.

PROCESS FOR RILPIVIRINE

The present invention provides a novel process for the preparation of 4-(4-hydroxypyrimidin-2-ylamino)benzonitrile. The present invention also provides a novel process for the preparation of 4-iodo-2,6-dimethyl benzenamine. The present invention further provides an improved process for the preparation of rilpivirine. The present invention further provides a tosylate salt of rilpivirine, process for its preparation and pharmaceutical compositions comprising it.