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189956-45-4

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189956-45-4 Usage

Chemical Properties

Light Brown Solid

Uses

4-N[2(4-hydroxypyriMidinyl)]aMinobenzonitrile is used in the preparation of 2-naphthyl substituted diarylpyrimidines (DAPY) analogues.

Check Digit Verification of cas no

The CAS Registry Mumber 189956-45-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,9,5 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 189956-45:
(8*1)+(7*8)+(6*9)+(5*9)+(4*5)+(3*6)+(2*4)+(1*5)=214
214 % 10 = 4
So 189956-45-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H8N4O/c12-7-8-1-3-9(4-2-8)14-11-13-6-5-10(16)15-11/h1-6H,(H2,13,14,15,16)

189956-45-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[(6-oxo-1H-pyrimidin-2-yl)amino]benzonitrile

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:189956-45-4 SDS

189956-45-4Relevant articles and documents

Industrial synthesis method of rilpivirine and intermediate compound

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Paragraph 0028; 0041; 0042; 0068; 0077; 0086; 0095; 0104, (2017/10/07)

The invention discloses an industrial synthesis method of rilpivirine. A compound as shown in a formula I and compound hydrochloride as shown in a formula VI react to obtain rilpivirine. The invention further discloses an intermediate compound as shown in the formula I and a synthesis method of the intermediate compound. Compared with the prior art, the synthesis method is simple to operate, mild in condition, high in yield and purity and suitable for industrial production.

4-[ (4-chloro-2-pyrimidinyl) amino] phenyl nitrile preparation method

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Paragraph 0032-0034, (2020/05/01)

The invention discloses a new preparation method of 4-[(4-chlorine-2-pyrimidyl)amino] cyanophenyl. The preparation method comprises the steps of carrying out a reaction on N-guanidine cyanophenyl and NN,-dimethyl amino acrylate to generate II, and then carrying out chlorination on equivalent phosphorus oxychloride to generate a target product. By adopting the preparation method, the yield and the quality of the product can be improved; the cost is reduced, and the method is simple and convenient to operate, and suitable for a synthetic route of rilpivirine bodbody in industrial production.

PROCESS FOR RILPIVIRINE

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Paragraph 0081, (2014/08/19)

The present invention provides a novel process for the preparation of 4-(4-hydroxypyrimidin-2-ylamino)benzonitrile. The present invention also provides a novel process for the preparation of 4-iodo-2,6-dimethyl benzenamine. The present invention further provides an improved process for the preparation of rilpivirine. The present invention further provides a tosylate salt of rilpivirine, process for its preparation and pharmaceutical compositions comprising it.

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