1228675-62-4

Upstream product

• 624-64-6 trans-2-Butene 
• 132969-60-9 (2S)-3-[(4-methoxybenzyl)oxy]-2-methylpropanal 
• 132969-71-2 methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 136320-64-4 (2R)-3-[(4-methoxybenzyl)oxy]-2-methylpropanol 

Downstream Products

• 1228675-70-4 (2R,3R,6S,8R,9R)-2-((benzyloxy)methyl)-8-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3,9-dimethyl-1,7-dioxaspiro[5.5]undecane 
• 1228675-63-5 (2S,3R,4R,E)-11-((tert-butyldimethylsilyl)oxy)-1-((4-methoxybenzyl)oxy)-2,4-dimethyl-7-((trimethylsilyl)methylene)undecan-3-ol 

Relevant academic research and scientific papers

Formal synthesis of tirandamycin B

A formal synthesis of tirandamycin B is described. The key intermediate is synthesized by Marshall allenyl zinc method, litiofuran coupling, and Achmatowicz reaction to construct the bicyclic core of tirandamycin B.

Polyketide assembly by alkene-alkyne reductive cross-coupling: Spiroketals through the union of homoallylic alcohols

A reaction sequence composed of regioselective formal hydroalkynylation, reductive ene-yne cross-coupling, and oxidative cyclization has been developed to prepare stereochemically dense spiroketals. Overall, the chemistry defines a three-component coupling process for the union of two homoallylic alcohol-based substrates with trimethylsilylacetylene.