1228682-81-2

Basic information

• Product Name: (E)-acrylaldehyde O-(1-phenylprop-2-yn-1-yl)oxime
• Synonyms: (E)-acrylaldehyde O-(1-phenylprop-2-yn-1-yl)oxime
• CAS NO: 1228682-81-2
• Molecular Weight: 185.225
• Mol File: 1228682-81-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-acrylaldehyde O-(1-phenylprop-2-yn-1-yl)oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-acrylaldehyde O-(1-phenylprop-2-yn-1-yl)oxime(1228682-81-2)
• EPA Substance Registry System: (E)-acrylaldehyde O-(1-phenylprop-2-yn-1-yl)oxime(1228682-81-2)

Safety Data

• Hazardous Substances Data: 1228682-81-2(Hazardous Substances Data)

Upstream product

• 107-02-8 acrolein 

Downstream Products

• 32361-74-3 3-benzylpyridine N-oxide 

Relevant articles and documents

Copper-catalyzed tandem [2,3]-Rearrangement and 6π-3-Azatriene electrocyclization in (E) -O -Propargylic α,β-Unsaturated oximes

Cu-catalyzed cyclizations of (E)-O-propargylic oximes of α,β-unsaturated aldehydes were successfully carried out to afford the corresponding pyridine oxides in good to high yields. As an example, (E)-acrylaldehyde O-1,3-diphenylprop-2-ynyl oxime (1b) was reacted for 5 h in the presence of CuBr(PPh3)3 (10 mol %) and PPh3 (10 mol %) in DMSO at 120 C to afford 3-benzyl-2-phenylpyridine-N-oxide (2b) in 84% yield. In this case, the reaction proceeded via Cu-catalyzed propargyl oxime-allenyl nitrone rearrangement followed by 6-3-azatriene electrocyclization.