1228689-40-4Relevant academic research and scientific papers
Asymmetric tandem wittig rearrangement/mannich reactions
Giampietro, Natalie C.,Wolfe, John P.
, p. 2922 - 2924 (2010)
Figure Presented The choice is yours: A highly stereoselective synthesis of α-alkyl-α-hydroxy-β-amino esters is accomplished through a tandem Wittig-rearrangement/Mannich reaction sequence. Transformations of N-benzyl or N-Boc imines proceed with high selectivity for formation of syn-amino alcohol derivatives, whereas N-Boc-2-(phenylsulfonyl)amines generate antiammo alcohol products. Auxiliary cleavage (transesterification or reduction) yields enantiomerically enriched products with up to 96% ee.
