1228690-72-9 Usage
Description
(2-Ethoxycarbonylmethylphenyl)boronic acid, pinacol ester is a chemical compound with the formula C16H21BO4. It is an ester derivative of the boronic acid group, commonly used in organic synthesis as a reagent for the Suzuki-Miyaura coupling reaction, a widely used method for forming carbon-carbon bonds in organic molecules. The pinacol ester group in the compound provides stability and steric hindrance, making it a valuable reagent for selective and efficient carbon-carbon bond formation.
Uses
Used in Organic Synthesis:
(2-Ethoxycarbonylmethylphenyl)boronic acid, pinacol ester is used as a reagent for the Suzuki-Miyaura coupling reaction, which is a widely used method for forming carbon-carbon bonds in organic molecules. The pinacol ester group in the compound provides stability and steric hindrance, making it a valuable reagent for selective and efficient carbon-carbon bond formation.
Used in Medicinal Chemistry and Drug Discovery:
(2-Ethoxycarbonylmethylphenyl)boronic acid, pinacol ester is important in the field of medicinal chemistry and drug discovery, as it can be used to synthesize complex organic molecules with potential pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1228690-72-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,6,9 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1228690-72:
(9*1)+(8*2)+(7*2)+(6*8)+(5*6)+(4*9)+(3*0)+(2*7)+(1*2)=169
169 % 10 = 9
So 1228690-72-9 is a valid CAS Registry Number.
1228690-72-9Relevant articles and documents
Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis
Scott, Jill M.,Baccei, Christopher,Bain, Gretchen,Broadhead, Alex,Evans, Jilly F.,Fagan, Patrick,Hutchinson, John H.,King, Christopher,Lorrain, Daniel S.,Lee, Catherine,Prasit, Peppi,Prodanovich, Pat,Santini, Angelina,Santini, Brian A.
, p. 6608 - 6612 (2011/12/04)
Biphenylacetic acid (5) was identified through a library screen as an inhibitor of the prostaglandin D2 receptor DP2 (CRTH2). Optimization for potency and pharmacokinetic properties led to a series of selective CRTH2 antagonists. Compounds demonstrated potency in a human DP2 binding assay and a human whole blood eosinophil shape change assay, as well as good oral bioavailability in rat and dog, and efficacy in a mouse model of allergic rhinitis following oral dosing.
