1228758-79-9Relevant academic research and scientific papers
Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives
Abdelhafez, Omaima M.,Amin, Kamelia M.,Batran, Rasha Z.,Maher, Timothy J.,Nada, Somaia A.,Sethumadhavan, Shalini
experimental part, p. 3371 - 3378 (2010/10/20)
The action of the coumarin-type drugs and related compounds is reviewed to their VKOR antagonistic effects. In our study, twenty 3-pyridinyl, pyrimidinyl and pyrazolyl-4-hydroxycoumarin derivatives were synthesized. A comparative in vivo (CT, PT determination) and in vitro (measurement of PIVKA-II levels) anticoagulant study with respect to warfarin showed that the synthesized compounds have different anticoagulant activities, the most prospective compounds were the 3-pyrazolyl-4-hydroxycoumarin derivatives.
