2748-33-6

Upstream product

• 57339-72-7 1-(4-hydroxy-2-oxo-2H-chromen-3-yl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 1022282-99-0 3-((2E)-3-(4-methoxyphenyl)prop-2-enoyl)-4-hydroxy-2(H)-chromen-2-one 

Downstream Products

• 1228758-79-9 4,5-dihydro-3-(4-hydroxy-2-oxo-2H-chromen-3-yl)-5-(4-methoxyphenyl)-N-phenylpyrazol-1-carbothioamide 
• 836678-28-5 3-[1-hydrazinoacetyl-5-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-hydroxy-chromen-2-one 
• 836678-26-3 3-[1-chloroacetyl-5-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-hydroxy-chromen-2-one 

Relevant academic research and scientific papers

The role of the intermolecular π···π interactions in the luminescence behavior of novel coumarin-based pyrazoline materials

Novel nine coumarin-based pyrazolines have been synthesized and fully characterized in search of new fluorescent compounds for design stimuli-responsive chromic materials. All reported compounds behave as highly fluorescent materials, both in solution and

Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives

The action of the coumarin-type drugs and related compounds is reviewed to their VKOR antagonistic effects. In our study, twenty 3-pyridinyl, pyrimidinyl and pyrazolyl-4-hydroxycoumarin derivatives were synthesized. A comparative in vivo (CT, PT determination) and in vitro (measurement of PIVKA-II levels) anticoagulant study with respect to warfarin showed that the synthesized compounds have different anticoagulant activities, the most prospective compounds were the 3-pyrazolyl-4-hydroxycoumarin derivatives.

Synthesis of some biologically active pyrazole, thiazolidinone, and azetidinone derivatives

Pyrazole, thiazolidinone, and azetidinone derivatives were synthesized from chalcones of 4-hydroxycoumarin. The structures of all the synthesized compounds were confirmed on the basis of spectral and analytical data. The compounds were screened in vitro for their antibacterial activity against various bacterial strains.