1228937-41-4

Basic information

• Product Name: (3α,5β,7α,12α)-3,7,12-trihydroxy-N-[(1E)-4-methoxyphenylmethylene]cholan-24-ohydrazide
• CAS NO: 1228937-41-4
• Molecular Weight: 540.744
• Mol File: 1228937-41-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3α,5β,7α,12α)-3,7,12-trihydroxy-N-[(1E)-4-methoxyphenylmethylene]cholan-24-ohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (3α,5β,7α,12α)-3,7,12-trihydroxy-N-[(1E)-4-methoxyphenylmethylene]cholan-24-ohydrazide(1228937-41-4)
• EPA Substance Registry System: (3α,5β,7α,12α)-3,7,12-trihydroxy-N-[(1E)-4-methoxyphenylmethylene]cholan-24-ohydrazide(1228937-41-4)

Safety Data

• Hazardous Substances Data: 1228937-41-4(Hazardous Substances Data)

Upstream product

• 80948-49-8 cholic acid hydrazide 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Synthesis and antimicrobial activity of cholic acid hydrazone analogues

Synthesis and antimicrobial activity of cholic acid analogues 4a-t are reported. The synthesis of 4a-t was accomplished from ethylcholate 2. The hydrazone moiety was introduced via coupling of the cholic acide hydrazide (3) with appropriately functionalized aldehyde utilizing acetic acid as a catalyst. Quiet of interest in relation to the synthesized hydrazones is the formation of two rotamers s-cis.E and s-trans.E. Most compounds showed stronger antimicrobial activity against Gram-positive bacteria than Cefaclor and Cefixime. Compounds 4d, 4i and 4j indicated 15-fold stronger antimicrobial activities against Enterobacter faecalis compared to Cefaclor and Cefixime. Some of the synthesized compounds (e.g. 4a, 4c, 4d, 4i, and 4l) reflected twofolds less activity against Escherichia coli relative to Cefixime.