1229-35-2 Usage
Description
Methdilazine Hydrochloride (200 MG), also known as Tacaryl Hydrochloride, is a light tan crystalline powder with a slight characteristic odor. It is a salt that is freely soluble in water and alcohol, and its activity is similar to that of methdilazine. Methdilazine Hydrochloride is primarily used for its antipruritic effect and is administered orally.
Uses
Used in Pharmaceutical Industry:
Methdilazine Hydrochloride (200 MG) is used as an antipruritic agent for the relief of itching associated with various skin conditions. It is particularly effective in treating itching caused by allergic reactions, skin rashes, and other dermatological issues.
Used in Medical Treatments:
Methdilazine Hydrochloride (200 MG) is used as a therapeutic agent in the treatment of patients suffering from severe itching due to skin conditions. Its administration helps alleviate the discomfort and distress caused by persistent itching, improving the patient's quality of life.
Brand Name:
Tacaryl (Westwood-Squibb) is the brand name under which Methdilazine Hydrochloride (200 MG) is marketed and distributed.
Originator
Tacaryl ,Westwood,US,1960
Manufacturing Process
10.8 parts of 10-(1-methyl-3-pyrrolidylmethyl) phenothiazine (prepared from 1-methyl-3-pyrrolidylmethyl chloride by reaction with phenothiazine) in 80 parts of 99% isopropyl alcohol were treated with a solution of 1.33 parts of hydrogen chloride in 30 parts of the same solvent. The clear light yellow solution soon deposited white crystals of the acid addition salt. After cooling overnight at 0°C, the crystalline product was collected on a filter, washed with 99% isopropyl alcohol and anhydrous ether and then dried in a vacuum oven at 95°C. Yield 10.4 parts, MP 187.5° to 189°C.
Therapeutic Function
Antipruritic
Air & Water Reactions
Water soluble. pH (1% aqueous solution) 4.8-6 .
Reactivity Profile
METHDILAZINE HYDROCHLORIDE (200 MG) is sensitive to exposure to light. An acidic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Fire Hazard
Flash point data for METHDILAZINE HYDROCHLORIDE (200 MG) are not available; however, METHDILAZINE HYDROCHLORIDE (200 MG) is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 1229-35-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,2 and 9 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1229-35:
(6*1)+(5*2)+(4*2)+(3*9)+(2*3)+(1*5)=62
62 % 10 = 2
So 1229-35-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3
