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Methdilazine hydrochloride

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  • Name Methdilazine hydrochloride
  • EINECSN/A
  • CAS No. 1229-35-2
  • Densityg/cm3
  • PSA31.78000
  • LogP5.04590
  • SolubilityN/A
  • Melting Point187.5-189°
  • FormulaC18H20 N2 S . Cl H
  • Boiling Point430.4°Cat760mmHg
  • Molecular Weight332.92
  • Flash Point214.1°C
  • Transport InformationN/A
  • AppearanceN/A
  • SafetyPoison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. Experimental reproductive effects. An antihistamine. When heated to decomposition it emits very toxic fumes of NOx and HCl.
  • Risk CodesN/A
  • Molecular Structure
    Molecular Structure of 1229-35-2 (METHDILAZINE HYDROCHLORIDE (200 MG))
  • Hazard SymbolsN/A
  • SynonymsN/A

Methdilazine hydrochloride Chemical Properties

IUPAC Name: 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine hydrochloride
Synonyms: 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine hydrochloride (1:1) ; 10-[(1-Methyl-3-pyrrolidinyl)methyl]phenothiazine hydrochloride ; 10-[(1-Methylpyrrolidin-3-yl)methyl]-10H-phenothiazine hydrochloride ; 10-[(1-Methylpyrrolidin-3-yl)methyl]-10H-phenothiazine hydrochloride (1:1) ; 10H-Phenothiazine, 10-[(1-Methyl-3-pyrrolidinyl)methyl]-, hydrochloride (1:1)
CAS NO: 1229-35-2
Molecular Formula of Methdilazine hydrochloride (CAS NO.1229-35-2) : C18H21ClN2S
Molecular Weight of Methdilazine hydrochloride (CAS NO.1229-35-2) : 332.89074
Molecular Structure of Methdilazine hydrochloride (CAS NO.1229-35-2) :
EINECS: 214-967-3
Mol File: 1229-35-2.mol
Flash Point: 214.1 °C
Enthalpy of Vaporization: 68.58 kJ/mol
Boiling Point: 430.4 °C at 760 mmHg
Vapour Pressure: 1.3E-07 mmHg at 25°C
General Description White microcrystalline powder with a slight odor. pH (1% aqueous solution) 4.8-6.
Air & Water Reactions: Water soluble. pH (1% aqueous solution) 4.8-6 .

Methdilazine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 25mg/kg (25mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
guinea pig LD50 oral 263mg/kg (263mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
mouse LD50 oral 190mg/kg (190mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
mouse LDLo intramuscular 300mg/kg (300mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.
mouse LDLo intravenous 25mg/kg (25mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.
rabbit LD50 intravenous 17mg/kg (17mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
rat LD50 oral 260mg/kg (260mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 2, Pg. 68, 1960.
rat LDLo intraperitoneal 75mg/kg (75mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.
rat LDLo intravenous 22mg/kg (22mg/kg)   Therapie. Vol. 15, Pg. 1064, 1960.

 

Methdilazine hydrochloride Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. Experimental reproductive effects. An antihistamine. When heated to decomposition it emits very toxic fumes of NOx and HCl.

Methdilazine hydrochloride Specification

Reactivity Profile: Methdilazine hydrochloride (200 MG) is sensitive to exposure to light. An acidic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

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