1229020-03-4

Basic information

• Product Name: C₁₀H₁₀ClNO₃S
• Synonyms: C₁₀H₁₀ClNO₃S
• CAS NO: 1229020-03-4
• Molecular Weight: 259.713
• Mol File: 1229020-03-4.mol

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₀ClNO₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₀ClNO₃S(1229020-03-4)
• EPA Substance Registry System: C₁₀H₁₀ClNO₃S(1229020-03-4)

Safety Data

• Hazardous Substances Data: 1229020-03-4(Hazardous Substances Data)

Upstream product

• 6609-58-1 2-propoxybenzonitrile 

Downstream Products

• 1229017-03-1 6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)-phenyl]pyrimidin-4(3H)-one 
• 1229017-16-6 5-fluoro-6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimidin-4(3H)-one 
• 1229019-16-2 5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one 
• 1229019-29-7 5-bromo-6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimidin-4(3H)-one 
• 1229019-28-6 5-iodo-6-ethyl-2-[2-n-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one 
• 1229019-36-6 5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide 
• 1229019-15-1 5-iodo-6-isopropyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H )-one 
• 1229016-98-1 6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one 

Relevant articles and documents

Utilization of halogen bond in lead optimization: A case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors

For proof-of-concept of halogen bonding in drug design, a series of halogenated compounds were designed based on a lead structure as new inhibitors of phosphodiesterase type 5. Bioassay results revealed a good correlation between the measured bioactivity and the calculated halogen bond energy. Our X-ray crystal structures verified the existence of the predicted halogen bonds, demonstrating that the halogen bond is an applicable tool in drug design and should be routinely considered in lead optimization.

PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF

The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following f