6609-58-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Propoxybenzonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a precursor for the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Propoxybenzonitrile is utilized as an intermediate for the production of agrochemicals. Its role in the synthesis of these compounds aids in the development of effective pesticides and other agricultural products.
Used in Dye Industry:
2-Propoxybenzonitrile is used as a starting material for the production of dyes. Its chemical properties make it suitable for the creation of a variety of dyes used in different applications, including textiles and other industries.
Used in Specialty Chemicals Production:
2-Propoxybenzonitrile is employed as a starting material for the synthesis of specialty chemicals. Its versatility in chemical reactions enables the production of unique and specialized chemical products for various applications.
Used in Chemical Reactions:
2-PROPOXYBENZONITRILE may undergo hydrolysis or oxidation reactions to form other chemical products. This ability to participate in various chemical transformations makes 2-Propoxybenzonitrile a valuable component in the synthesis of a wide array of chemical entities.

InChI:InChI=1/C10H11NO/c1-2-7-12-10-6-4-3-5-9(10)8-11/h3-6H,2,7H2,1H3

Upstream product

• 611-20-1 salicylonitrile 
• 106-94-5 propyl bromide 
• 107-08-4 1-iodo-propane 
• 71-23-8 propan-1-ol 
• 394-47-8 2-fluorobenzonitrile 
• 74-96-4 ethyl bromide 
• 59643-84-4 2-n-propoxybenzamide 

Downstream Products

• 57075-84-0 2-n-propoxybenzamidine hydrochloride 
• 37806-31-8 (2-propoxyphenyl)methanamine 
• 1229019-15-1 5-iodo-6-isopropyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H )-one 
• 1229016-98-1 6-isopropyl-2-[2-n-propoxy-5-(4-methyl-piperazin-1-yl-sulfonyl)phenyl]pyrimid-4(3H)-one 
• 1229019-36-6 5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxybenzimidamide 
• 1229019-31-1 2-propoxy-5-(4-methylpiperazin-1-yl)sulphonylbenzonitrile 
• 1229019-28-6 5-iodo-6-ethyl-2-[2-n-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one 
• 1229019-29-7 5-bromo-6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimidin-4(3H)-one 
• 1229019-16-2 5-chloro-6-ethyl-2-[2-n-propoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one 
• 1229017-16-6 5-fluoro-6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimidin-4(3H)-one 
• 1229020-03-4 C₁₀H₁₀ClNO₃S 
• 1229017-03-1 6-ethyl-2-[2-propoxy-5-(4-methyl-1-piperazinylsulfonyl)-phenyl]pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many proteins involved in cell adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and mutant myocilin. Grp94 has been implicated as a target for several therapeutic areas including glaucoma, cancer metastasis, and multiple myeloma. While 85% identical to other Hsp90 isoforms, the N-terminal ATP-binding site of Grp94 possesses a unique hydrophobic pocket that was used to design isoform-selective inhibitors. Incorporation of a cis-amide bioisostere into the radamide scaffold led to development of the original Grp94-selective inhibitor, BnIm. Structure-activity relationship studies have now been performed on the aryl side chain of BnIm, which resulted in improved analogues that exhibit better potency and selectivity for Grp94. These analogues also manifest superior antimigratory activity in a metastasis model as well as enhanced mutant myocilin degradation in a glaucoma model compared to BnIm.

Two ways of preparing benzonitriles using BrCCl3-PPh3 as the reagent

Benzamides were converted into benzonitriles with BrCCl3- PPh3-Et3N in CH2Cl2 in an Appel-type reaction. Benzaldoximes could be transformed to benzonitriles under identical conditions. It was found that the reaction system BrCCl3-(2 equiv.)PPh3 was also suitable for these transformations with PPh 3 replacing Et3N.

Triton B-mediated efficient and convenient alkoxylation of activated aryl and heteroaryl halides

A simple and convenient one-pot synthesis of aryl alkyl ethers by the alkoxylation of aryl halides with alcohol in the presence of Triton B as a base is described. The procedure is applicable for a variety of aryl and heteroaryl halides, and yields are very good. The use of a nonmetallic base and solvent-free conditions are important features of the reaction. Copyright Taylor & Francis Group, LLC.

Novel imidazotriazinones and the use thereof

Novel imidazotrizinones of general formula (I), a method for the production and the pharmaceutical use thereof are disclosed.

2-Phenyl-substituited Imidazotriazinones as Phoshodiesterase Inhibitors

2-(Sulfamoyl-substituted phenyl)-3H-imidazo (5,1-f) (1,2,4) triazin-4-ones (I) are new. Imidazotriazinones of formula (I) and their salts, N-oxides and isomeric forms are new: R1 = H or 1-4C alkyl; R2 = 1-4C straight chain alkyl; R3, R4 = H, 2-8C alkenyl, 1-8C alkoxy or 1-10C alkyl (optionally interrupted by O and/or substituted by a very wide range of specific groups); or R3 or R4 = NR20R21, adamantyl, 2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl, sulfolanyl, hydroxy-sulfolanyl, 2-oxo-tetrahydrofuran-3-yl; or 3-8C cycloalkyl, 6-10C aryl or 5-7 membered heterocycle, all optionally substituted by specific groups; or NR3R4 = (a) optionally benzo-fused, saturated, partially unsaturated or unsaturated 5-7 membered heterocycle, optionally containing 1-3 of S, N, O and NR37 and optionally substituted by a very wide range of specific groups; or (b) a group of formula (i)-(iv); R20,R21 = H or 1-6C alkyl; R37 = H, OH, CHO, CF3, up to 4C acyl, up to 4C alkoxycarbonyl, 1-4C alkoxy, 1-6C alkyl (optionally substituted by specific groups) or -(CO)iE; i = 0 or 1; E = 3-7C cycloalkyl or benzyl; 6-10C aryl or 5- or 6-membered heteroaryl, both optionally substituted by specific groups ; or 5-methyl-1-oxo-2,1,3-oxadiazol-4-yl, N-methylpiperazino or morpholino; R5,R6 = H, 1-6C alkyl, OH or 1-6C alkoxy. The full definitions are given in the DEFINITIONS (Full Definitions) field. An Independent claim is included for the preparation of (I).

7-alkyl- and cycloalkyl-substituted imidazotriazinones

The present invention relates to 7-alkyl- and cycloalkyl-substituted imidazotriazinones, to processes for their preparation and to their use as medicaments, in particular as inhibitors of cGMP-metabolizing phosphodiesterases.

2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors

The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.