1229037-82-4Relevant academic research and scientific papers
Synthesis and biological evaluation of Raddeanin A, a triterpene saponin isolated from Anemone raddeana
Qian, Shan,Chen, Quan Long,Guan, Jin Long,Wu, Yong,Wang, Zhou Yu
, p. 779 - 785 (2016/10/12)
First, Raddeanin A, a cytotoxic oleanane-type triterpenoid saponin isolated from Anemone raddeana REGEL, was synthesized. Stepwise glycosylation was adopted in the synthesis from oleanolic acid, employing arabinosyl, glucosyl and rhamnosyl trichloroacetimidate as donors. The chemical structure of Raddeanin A was confirmed by means of 1H-NMR, 13C-NMR, IR, MS and elemental analysis, which elucidated the structure to be 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranoside oleanolic acid. Biological activity tests showed that in the range of low concentrations, Raddeanin A displayed moderate inhibitory activity against histone deacetylases (HDACs), indicating that the HDACs' inhibitory activity of Raddeanin A may contribute to its cytotoxicity.
Facile synthesis of four natural triterpene saponins with important antitumor activity
Guo, Tiantian,Liu, Qingchao,Zhang, Lei,Wang, Peng,Li, Yingxia
scheme or table, p. 357 - 371 (2011/04/18)
The first synthesis of four natural triterpene saponins, which exhibit significant antitumor activities, was concisely achieved by adopting a stepwise glycosylation. The key intermediate 13 was afforded via Bu2SnO-mediated regioseletive benzoylation. Duri
Synthesis and α-glucosidase inhibitory activity of oleanolic acid derivatives
Qian, Shan,Hai Li, Jiao,Wei Zhang, Yu,Chen, Xin,Wu, Yong
scheme or table, p. 20 - 29 (2010/09/18)
Glucosidations of oleanolic acid (1) and its dihydroxy-olide derivatives (2) were carried out to provide eight glycosides. All synthesized compounds were evaluated by in vitro α-glucosidase inhibitory activity assay. 3-Acetyl dihydroxy-olide oleanolic der
