149707-76-6

Upstream product

• 627466-84-6 2,3,4,6-tetra-O-benzoyl-D-galactose 
• 545-06-2 trichloroacetonitrile 
• 2592-58-7 1,2,3,4,6-Penta-O-benzoyl-α-D-galactopyranose 
• 2592-58-7 1,2,3,4,6-penta-O-benzoyl-α-D-galactopyranoside 
• 61198-88-7 2,3,4,6-tetra-O-benzoyl-α-D-galactopyranosyl bromide 
• 3646-73-9 α-D-galactopyranose 
• 98-88-4 benzoyl chloride 
• 113544-55-1 2,3,4,6-tetra-O-benzoyl-α-D-galactopyranose 
• 7296-64-2 β-D-galactopyranoside 
• 2592-58-7 1,2,3,4,6-penta-O-benzoyl-β-D-galactopyranose 
• 627466-64-2 2,3,4,6-tetra-O-benzoyl-D-glucopyranose 
• 2592-58-7 1,2,3,4,6-penta-O-benzoyl-D-glucopyranoside 
• 14218-11-2 2,3,4,6-tetra-O-benzoylglucosyl bromide 
• 2280-44-6 D-Glucose 

Downstream Products

• 192126-03-7 C₄₉H₅₈O₁₄SSi 
• 207284-73-9 C₄₄H₄₈O₁₂Si 
• 206257-81-0 (R)-1-dimethylthexylsilyloxy-3-butene-2-yl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranoside 
• 350243-33-3 1-O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-3,4-O-isopropylidene-5,6-di-O-tetradecyl-D-mannitol 
• 350243-30-0 1-O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-3-O-benzyl-5,6-di-O-tetradecyl-D-glucitol 
• 431062-51-0 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl-(1->3)-6-O-tert-butyldiphenylsilyl-1,2-O-ethylidene-α-D-galactopyranose 
• 431062-48-5 methyl 2,3,5-tri-O-benzoyl-α-L-arabinofuranosyl-(1->6)-[2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl-(1->3)]-2-O-acetyl-α-D-galactopyranoside 
• 70751-57-4 C₄₆H₄₆O₁₅ 
• 492454-33-8 C₆₉H₆₂O₂₂ 
• 212128-08-0 phenyl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl-(1->6)-2,3,4-tri-O-benzoyl-1-thio-β-D-galactopyranoside 
• 821018-29-5 phenyl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl-(1->6)-2,4-di-O-benzoyl-3-O-chloroacetyl-β-D-galactopyranosyl-(1->6)-2,3,4-tri-O-benzoyl-1-thio-β-D-galactopyranoside 
• 865294-29-7 4-methoxyphenyl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl-(1->3)-6-O-acetyl-2,4-di-O-benzoyl-β-D-galactopyranoside 
• 908835-51-8 C₈₆H₉₇NO₁₇ 
• 1008131-08-5 benzyl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl-(1->4)-2,3-isopropylidene-α-L-rhamnopyranoside 

Relevant academic research and scientific papers

VACCINE COMPOSITIONS AND ANTIBODIES FOR LYME DISEASE

The present invention relates to vaccine compositions comprising lipid antigens, antibodies targeting lipid antigens, pharmaceutical compositions comprising such and their use in diagnosing, monitoring, treating, and preventing infectious disease, such as Lyme disease. In one aspect, administered is a therapeutically effective amount of a vaccine composition comprising a lipid antigen, an antibody or fragment thereof binding a lipid antigen, and/or a pharmaceutical composition comprising an antibody or fragment thereof binding a lipid antigen. Other aspects are described.

Experimental and theoretical study of the O3/O4 regioselectivity of glycosylation reactions of glucopyranosyl acceptors

The knowledge of the regioselectivity between different hydroxyl groups of glycosyl acceptors is valuable in planning simple strategies for the synthesis of oligosaccharides, minimizing the use of protecting groups. With the aim of obtaining deeper knowle

ENDOSOMAL CLEAVABLE LINKERS

The present disclosure relates generally to cleavable linkers and uses thereof.

The dehydroepiandrosterone and dehydroepiandrosterone alkone glycosylation derivative and its preparation method and application

The invention discloses epiandrosterone glycosylation derivatives and dehydrogenated epiandrosterone glycosylation derivatives, and a preparation method thereof. The preparation method comprises the following steps: respectively carrying out coupling reac

3 - monosaccharide acid oxygen glucoside oleanolic alkane type and wusu alkane triterpene saponin derivative and its preparation method and application

The invention discloses a 3-monouronic acid o-glycoside oleanane type and ursane type triterpenoid saponin derivative. The derivative has a structural formula as shown in the specification, wherein R4 is one of H atom, alkyl containing 1-10 carbons, alkyl

Cross metathesis assisted solid-phase synthesis of glycopeptoids

A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good yield

Mitochondrial affinity of guanidine-rich molecular transporters built on monosaccharide scaffolds: Stereochemistry and lipophilicity

We synthesized eight G8 molecular transporters (MTs) based on 4 different monosaccharide scaffolds, and studied their biological properties with a special focus on possible mitochondrial targeting and tissue selectivity. The mitochondrial affinity of these MTs was found to be clearly related to the scaffold stereochemistry and also tenuously with the lipophilicity. It may be suggested that in the practical delivery strategy of drugs for the brain and mitochondrial diseases the BBB permeability and mitochondrial affinity should be considered as key parameters, and that an enhanced mitochondrial affinity appears possible by further research on the structure-property relationship of guanidine-rich molecular transporters.

Synthesis of some phenylpropanoid glycosides (PPGs) and their acetylcholinesterase/xanthine oxidase inhibitory activities

In this research, three categories of phenylpropanoid glycosides (PPGs) were designed and synthesized with PPGs isolated from Rhodiola rosea L. as lead compounds. Their inhibitory abilities toward acetylcholinesterase (AChE) and xanthine oxidase (XOD) were also tested. Some of the synthetic PPGs exhibited excellent enzyme inhibitory abilities.

Antifungal activity of 2α,3β-functionalized steroids stereoselectively increases with the addition of oligosaccharides

Invasive fungal infections pose a significant problem to the immune-compromised. Moreover, increased resistance to common antifungals requires development of novel compounds that can be used to treat invasive fungal infections. Naturally occurring steroid

SnCl4- and TiCl4-catalyzed anomerization of acylated O - And S -glycosides: Analysis of factors that lead to higher α: β d reaction rates

The quantification of factors that influence both rates and stereoselectivity of anomerization reactions catalyzed by SnCl4 and TiCl4 and how this has informed the synthesis of α-O- and α-S-glycolipids is discussed. The SnCl4-catalyzed anomerization reactions of β-S- and β-O-glycosides of 18 substrates followed first order equilibrium kinetics and kf + kr values were obtained, where kf is the rate constant for the forward reaction (β → α) and kr is the rate constant for the reverse reaction (α → β). Comparison of the kf + k r values showed that reactions of glucuronic acid or galacturonic acid derivatives were ～10 to 3000 times faster than those of related glucoside and galactopyranoside counterparts and α:β ratios were generally also higher. Stereoelectronic effects contributed from galacto-configured compounds were up to 2-fold faster than those of corresponding glucosides. The introduction of groups, including protecting groups, which are increasingly electron releasing generally led to rate enhancements. The anomerization of S-glycosides was consistently faster than that of corresponding O-glycosides. Reactions were generally faster for reactions with TiCl4 than those with SnCl4. Anomeric ratios depended on the Lewis acid, the number equivalents of the Lewis acid, temperature, and substrate. Very high ratios of α-products for both O- and S-glucuronides were observed for reactions promoted by TiCl4; for these substrates TiCl4 was superior to SnCl4. Anomeric ratios from anomerization of S-glucosides were higher with SnCl4 than with TiCl4. The dependence of equilibrium ratio on Lewis acid and the number of equivalents of Lewis acid indicated that the equilibrium ratio is determined by a complex of the saccharide residue bound to the Lewis acid and not the free glycoside. The high α:β ratios observed for anomerization of both O- and S-glycuronic acids can be explained by coordination of the C-1 heteroatom and C-6 carbonyl group of the product to the Lewis acid, which would enhance the anomeric effect by increasing the electron-withdrawing ability of the anomeric substituent and lead to an increase in the proportion of the α-anomer. Such an observation would argue against the existence of a reverse anomeric effect. Support for a chelation-induced endocyclic cleavage mechanism for the anomerization is provided by the trapping of a key intermediate. The data herein will help predict the tendency of β-glycosides to undergo anomerization; this includes cases where 1,2-trans glycosides are initial products of glycosidation reactions catalyzed by TiCl4 or SnCl4.