1229224-93-4 Usage
Uses
Used in Pharmaceutical Industry:
Cinacalcet Impurity is used as a quality control parameter for ensuring the safety and efficacy of cinacalcet formulations. Monitoring and controlling the levels of these impurities is essential to comply with regulatory guidelines and maintain the therapeutic benefits of the drug for patients with secondary hyperparathyroidism and parathyroid carcinoma.
Cinacalcet Impurity is used as a research subject for understanding the synthesis process of cinacalcet and identifying potential impurities that may affect the drug's performance. This knowledge aids in refining the manufacturing process and improving the overall quality of cinacalcet formulations.
Used in Regulatory Compliance:
Cinacalcet Impurity is used as a benchmark for regulatory agencies such as the US Food and Drug Administration (FDA) to establish guidelines and standards for monitoring and controlling impurities in pharmaceutical products like cinacalcet. Adhering to these guidelines ensures the quality and safety of the drug for patients, minimizing potential risks associated with impurities.
Check Digit Verification of cas no
The CAS Registry Mumber 1229224-93-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,9,2,2 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1229224-93:
(9*1)+(8*2)+(7*2)+(6*9)+(5*2)+(4*2)+(3*4)+(2*9)+(1*3)=144
144 % 10 = 4
So 1229224-93-4 is a valid CAS Registry Number.
1229224-93-4Relevant articles and documents
HIGHLY PURE CINACALCET OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
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Page/Page column 46, (2010/07/02)
Provided herein are impurities of cinacalcet, (R)-α-methyl-N-[3-[3-(trifluoromethyl) phenyl]propyl]-1-(5,6,7,8-tetrahydronaphthalene)methaneamine (tetrahydro cinacalcet impurity), (R)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1- naphthalenemethaneamine-N-oxide (cinacalcet N-oxide impurity) and (R)-α-methyl-N-[3-[3- (trifiuoromethyl)phenyl]methyl]-1-naphthalenemethaneamine (benzylamine impurity); and processes for preparation and isolation thereof. Provided further herein is a highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities, processes for the preparation thereof, and pharmaceutical compositions comprising highly pure cinacalcet or a pharmaceutically acceptable salt thereof substantially free of impurities.
