1229244-95-4

Upstream product

• 1229244-99-8 methyl 3-bromo-5-(3-methoxypropyl)-4-methylbenzoate 
• 1229245-00-4 methyl 3-bromo-5-[(1E)-3-methoxy-1-propen-1-yl]-4-methylbenzoate 
• 74896-66-5 Methyl 3,5-Dibromo-4-methylbenzoate 

Downstream Products

• 1229244-94-3 methyl 3-bromo-5-[3-(difluoromethoxy)propyl]-4-methylbenzoate 
• 1266728-09-9 methyl 3-bromo-4-methyl-5-{3-[(triisopropylsilyl)oxy]propyl}benzoate 
• 1266728-10-2 (3-bromo-4-methyl-5-{3-[(triisopropylsilyl)oxy]propyl}phenyl)methanol 
• 1266728-08-8 {3-[3-bromo-5-(bromomethyl)-2-methylphenyl]propoxy}(triisopropyl)silane 

Relevant academic research and scientific papers

RENIN INHIBITORS

Renin inhibitors, which are spirocyclic piperidine amides, of structural formula (I) and pharmaceutical compositions thereof useful in the treatment of cardiovascular diseases and renal insufficiency, wherein n, for each instance in which it occurs, is independently 0, 1, or 2; R1 is hydrogen, C1-6 -alkyl or C3-6 -cycloalkyl, wherein said C1-6 -alkyl or C3-6 -cycloalkyl group can be independently substituted with 1-3 halogens; A is (i) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic monocyclic ring or (ii) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring which is fused to another five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring, V is a bond or -(C=O)-, -CH(OH)-, -CH2- or =CH-; U is a bond or -CH2-, or for the case when V is =CH-, U is -CH=; X is =CH-, =CF-, =C(OR3)-, or -C=O-; and Y is =CH-, =CF-, =N-, or for the case when X is -C=O-, Y is -N(R3)-.

3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS

The present invention relates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-position lsoqumolone and having the Formula (I) : The invention further relates to pharmaceutical compositions containing said compounds, as well a