122946-92-3Relevant academic research and scientific papers
A SIMPLE SYNTHESIS OF 2-VINILINDOLES
Macor, John E.,Newman, Michael E.,Ryan, Kevin
, p. 2509 - 2512 (2007/10/02)
A two step synthesis of 2-vinyl indoles is described.Reaction of the anions of 2-methylindole-3-carboxylates (1) and (5) with ketones and aldehydes leads directly to 2-vinylindole-3-carboxylic acids (3) and esters (7), respectively.Decarboxylation of the acids (3) yields the desired 2-vinylindoles (4).
Synthesis of Pyranoindoles as Conformationally Restricted Analogues of the Serotonin Antagonist ICS 205-930 and as Precursors to 2-Vinylindoles
Macor, John E.,Ryan, Kevin,Newman, Michael E.
, p. 4785 - 4795 (2007/10/02)
A useful synthesis of some pyranoindoles is described that allows access to conformationally restricted analogues of the serotonin (5HT3) antagonist, ICS 205-930.These pyranoindoles can be converted in one step to 2-vinylindole derivatives.
