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1229627-05-7

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1229627-05-7 Usage

Description

1-(Boc-aMino)-3-(isopropylaMino)propane is a versatile chemical compound with the molecular formula C11H24N2O2. It is a derivative of aminopropane, featuring a tert-butoxycarbonyl (Boc) group attached to the amino group, which serves to protect the amino group during peptide synthesis and other organic reactions. The presence of an isopropylamino group further enhances its reactivity, making it a valuable chemical building block with potential applications across various industries, including pharmaceuticals, agrochemicals, and material sciences.

Uses

Used in Pharmaceutical Industry:
1-(Boc-aMino)-3-(isopropylaMino)propane is used as a synthetic intermediate for the development of pharmaceutical compounds. Its protected amino group and isopropylamino functionality allow for the creation of complex molecular structures with specific biological activities, contributing to the discovery of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(Boc-aMino)-3-(isopropylaMino)propane is utilized as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique chemical properties enable the development of novel compounds with improved efficacy and selectivity, enhancing crop protection and yield.
Used in Material Science:
1-(Boc-aMino)-3-(isopropylaMino)propane is employed as a building block in the synthesis of advanced materials, including polymers and composites. Its reactivity and functional groups allow for the creation of materials with tailored properties, such as improved mechanical strength, thermal stability, or specific chemical reactivity, for use in various applications, including coatings, adhesives, and electronic devices.

Check Digit Verification of cas no

The CAS Registry Mumber 1229627-05-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,9,6,2 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1229627-05:
(9*1)+(8*2)+(7*2)+(6*9)+(5*6)+(4*2)+(3*7)+(2*0)+(1*5)=157
157 % 10 = 7
So 1229627-05-7 is a valid CAS Registry Number.

1229627-05-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Carbamic acid, N-?[3-?[(1-?methylethyl)?amino]?propyl]?-?, 1,?1-?dimethylethyl ester

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1229627-05-7 SDS

1229627-05-7Upstream product

1229627-05-7Downstream Products

1229627-05-7Relevant articles and documents

Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile

Du, Wenxin,Hu, Xiaobei,Jin, Tingting,Kan, Weijuan,Li, Jia,Li, Kun,Liu, Tao,Wang, Chang,Wang, Peipei,Wu, Zhiqi,Xu, Lei,Zhang, Runyuan,Zhou, Yubo

, p. 15069 - 15090 (2021/11/13)

Checkpoint kinase 1 (CHK1) plays an important role in the DNA damage response pathway, being a potential anti-cancer drug target. In this study, we used a strategy for trifluoromethyl substitution to obtain orally bioavailable CHK1 inhibitors to overcome the limitations of lead compound 1, which can only be administered intravenously. After detailed investigation, we identified compound 6c as an oral CHK1 inhibitor, which demonstrated a considerably higher plasma exposure in mice. Compound 6c also showed good kinase selectivity. Moreover, it exhibited a significant antiproliferative effect in MV-4-11 cells singly and a synergistic effect in combination with gemcitabine in HT-29, A549, and RPMI-8226 cells. Additionally, compound 6c could inhibit tumor growth in the MV-4-11 xenograft mouse model. The combination of 6c and gemcitabine exhibited synergistic effect in the HT-29 xenograft mouse model. Thus, compound 6c was found to be a selective and oral potential anticancer CHK1 inhibitor.

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