1229649-08-4Relevant academic research and scientific papers
Reversal of Selectivity in C3-Allylation and Formal [3 + 2]-Cycloaddition of Spiro-epoxyoxindole: Unified Synthesis of Spiro-furanooxindole, (±)-N-Methylcoerulescine, (±)-Physovenine, and 3a-Allylhexahydropyrrolo[2,3-b]indole
Hajra, Saumen,Roy, Sayan,Maity, Subrata
, p. 1998 - 2001 (2017)
An effective Lewis acid catalyzed regioselective C3-allylation and a formal [3 + 2]-annulation reaction of spiro-epoxyoxindoles have been developed and can be accessed simply by changing the reaction conditions. This method has been successfully employed for the synthesis of spiro(pyrrolidinyloxindole), 3a-allylhexahydropyrrolo[2,3-b]indole, and furanoindoline.
Applications of NHC-mediated O- to C-carboxyl transfer: synthesis of (±)-N-benzyl-coerulescine and (±)-horsfiline
Thomson, Jennifer E.,Kyle, Andrew F.,Ling, Kenneth B.,Smith, Siobhan R.,Slawin, Alexandra M.Z.,Smith, Andrew D.
experimental part, p. 3801 - 3813 (2010/07/02)
NHC-promoted O- to C-carboxyl transfer of 3-allyl indolyl phenyl carbonates generates 3-allyl-3-phenoxycarbonyl-oxindoles with good catalytic efficiency, which are readily converted into (±)-N-benzyl-coerulescine and (±)-horsfiline.
