1229652-46-3Relevant academic research and scientific papers
Organocatalytic enantioselective hydroxymethylation of oxindoles with paraformaldehyde as C1 unit
Liu, Xiong-Li,Liao, Yu-Hua,Wu, Zhi-Jun,Cun, Lin-Feng,Zhang, Xiao-Mei,Yuan, Wei-Cheng
supporting information; experimental part, p. 4872 - 4875 (2010/10/19)
(Figure Presented) A bifunctional thiourea-tertiary amine-catalyzed asymmetric hydroxymethylation of 3-substituted oxindoles using paraformaldehyde as the C1 unit was developed. A wide scope of oxindoles, bearing C3 sterically congested quaternary carbon centers, were smoothly obtained in good to excellent yields (up to 99%) and high enantioselectivities (up to 91% ee) under mild reaction conditions. A more significant feature of this approach employs cheap and readily available paraformaldehyde as a hydroxymethylation C1 unit, which is activated by chiral bifunctional thiourea organocatalysts.
