122977-46-2

Basic information

• Product Name: 2-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester
• Synonyms: 2-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester
• CAS NO: 122977-46-2
• Molecular Weight: 266.251
• Mol File: 122977-46-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester(122977-46-2)
• EPA Substance Registry System: 2-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-methyl ester(122977-46-2)

Safety Data

• Hazardous Substances Data: 122977-46-2(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 106-65-0 Dimethyl succinate 

Downstream Products

• 111265-97-5 (R)-(+)-methyl α-vanillylhemisuccinate 
• 111265-98-6 (S)-2-(4-Hydroxy-3-methoxy-benzyl)-succinic acid 1-methyl ester 
• 186411-99-4 2-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-butane-1,4-diol 
• 186411-87-0 dimethyl (E)-2-(4-hydroxy-3-methoxybenzylidene)succinate 
• 111194-04-8 3-methoxycarbonyl-4-(4-hydroxy-3-methoxyphenyl)butanoic acid 

Relevant articles and documents

Efficient Asymmetric Syntheses of Naturally Occurring Lignan Lactones Using Catalytic Asymmetric Hydrogenation as a Key Reaction

Optically pure (R)-arylmethylsuccinic acid mono-methyl esters were obtained efficiently by using the catalytic asymmetric hydrogenation of arylidenesuccinic acid monoesters with a rhodium(I) complex of a chiral bisphosphine, (4S,5S)-MOD-DIOP.Asymmetric total syntheses of some naturally occurring lignans, (+)-collinusin, (-)-deoxypodophyllotoxin, and (+)-neoisostegane, were achieved via several steps from (R)-γ-butyrolactones as key intermediates obtained by reduction of (R)-arylmethylsuccinic acid mono methyl-esters.

THE SYNTHESES OF (R)-(+)-β-VANILLYL-γ-BUTYROLACTONE AND OF CHIRAL LIGNANS THEREFROM

(R)-(+)-β-vanillyl-γ-butyrolactone was obtained in 4 steps including a resolution, from vanillin and dimethyl succinate, and was used for the total syntheses of 5 naturally occurring and optically active lignans such as (+)-isolariciresinol 20.