186411-87-0Relevant academic research and scientific papers
First Total Synthesis of (±)-Rhodoconferimide
Pandhade, Kailas R.,Argade, Narshinha P.
, p. 658 - 662 (2018)
Starting from vanillin and dimethyl maleate, a concise and efficient racemic total synthesis of the potent antioxidant marine natural product (±)-rhodoconferimide has been carried out via the Wittig reaction, catalytic hydrogenation, selective brominations, and imide formation. An appropriate regioselective double bromination of the aromatic ring was a key step in the synthesis.
An Easy Procedure for the Preparation of 3-Methylidenetetrahydrofurans from Dimethyl Succinates
Corral, Jose M. Miguel,Gordaliza, Marina,Castro, M. Angeles,Salinero, Miguel A.,Dorado, Jose M.,Feliciano, Arturo San
, p. 154 - 164 (2007/10/03)
A new synthetic proceduree to obtain 3-methylidenetetrahydrofurans is described, in which the methylidene group is generated during the formation of the tetrahydrofuran ring. These are prepared by reduction of differently substituted dimethyl succinates obtained by Stobbe condensation.
