1229893-66-6Relevant articles and documents
Chromium-catalyzed homoaldol equivalent reaction employing a nucleophilic propenyl acetate
Kang, Jun Yong,Connell, Brian T.
supporting information; experimental part, p. 7826 - 7827 (2010/08/04)
A scalable, highly regioselective chromium-catalyzed homoaldol equivalent reaction employing 3-bromopropenyl acetate as a masked homoenolate nucleophile in additions to aromatic, aliphatic, and α,β-unsaturated aldehydes under mild Cr/Mn redox conditions in good to excellent yields is reported. The resulting vinyl acetate-containing adducts are easily hydrolyzed with mild base to provide formal homoaldol adducts, or transformed to other more functionalized products by stereoselective transformations including epoxidation and cyclopropanation.