36866-66-7

Usage

Uses

Used in Food and Beverage Industry:
2-Furanol, tetrahydro-5-phenylis used as a flavoring agent for its sweet, caramel-like aroma and taste, enhancing the flavor profiles of various food and beverage products.
Used in Perfumes and Cosmetics:
2-Furanol, tetrahydro-5-phenylis used as a fragrance ingredient in perfumes and cosmetics, contributing to the creation of pleasant and long-lasting scents.
Used in Pharmaceutical and Biotechnology Research:
2-Furanol, tetrahydro-5-phenylis studied for its potential biological and pharmacological properties, such as antimicrobial and antioxidant activities, which may lead to the development of new drugs and therapies.

Upstream product

• 22927-18-0 2-Phenyl-4-hydroxy-butyraldehyd 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 74141-11-0 trans-1-Phenyl-2-buten-1,4-diol 
• 143169-59-9 2-(2-Phenylcyclopropyl)glycine 
• 143123-94-8 2-Methoxy-3-carboxy-5-phenyltetrahydrofuran 
• 104824-00-2 5-phenyl-2-trimethylsilyl-4,5-dihydrofuran 
• 4850-50-4 1-phenyl-butane-1,4-diol 
• 100-52-7 benzaldehyde 
• 622860-41-7 trans-1,5-diphenyl-4-penten-1-ol 
• 201230-82-2 carbon monoxide 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 638-37-9 butanedial 
• 591-51-5 phenyllithium 
• 2051-95-8 succinylbenzene 

Downstream Products

• 83268-77-3 6-phenyl-2,2-(trimethylenedithio)tetrahydropyran 
• 114647-05-1 (Z)-2-Dimethylamino-6-hydroxy-6-phenyl-hex-2-enenitrile 
• 16133-83-8 tetrahydro-2-phenylfuran 
• 4850-50-4 1-phenyl-butane-1,4-diol 
• 1187461-93-3 (E)-5-cyclopropyl-1-phenylpent-4-en-1-ol 
• 1187461-79-5 (E)-methyl 6-hydroxy-6-phenylhex-2-enoate 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 

Relevant academic research and scientific papers

Cobalt-catalysed addition of allylidene dipivalate to aldehydes. A formal homoaldol condensation

A Co(I)-catalysed condensation of allylidene dipivalate with aldehydes to give (Z)-4-hydroxybut-1-enyl pivalates in 62 to 87% isolated yields, is reported. Reactions are run in acetonitrile at 0 or 25°C depending on the nature of the aldehyde, and exploit

Aerobic oxidation of primary alcohols in the presence of activated secondary alcohols

Chemoselective aerobic oxidation of primary alcohols in the presence of activated secondary alcohols was effected under irradiation of visible light by using (nitrosyl)Ru(salen) complex 6 that possesses bulky 1-ethyl-1-methylpropyl groups at C3, C3′, C5 a

Selective mono addition of aryllithiums to dialdehydes by micromixing

Micromixing enables highly selective mono addition of aryllithiums to dialdehydes. Because the unchanged formyl group in the products can be used for further transformations, the present approach serves as a powerful method for protecting-group-free synthesis.

SYNTHETIC INTERMEDIATE OF 1-(2-DEOXY-2-FLUORO-4-THIO-?-D-ARABINOFURANOSYL)CYTOSINE, SYNTHETIC INTERMEDIATE OF THIONUCLEOSIDE, AND METHOD FOR PRODUCING THE SAME

A compound represented by a formula [1D] as shown below (wherein R1A, R1B, R2A, R2B, R3A and R3B represent a hydrogen atom, an optionally substituted C1-6 alkyl group, and the li

Unusual aluminum hydride-mediated reduction of N-(γ- or δ-oxoacyl)oxazolidinone

Reduction of N-(γ-oxoacyl)oxazolidinone with a borohydride reagent, such as NaBH4 or LiBEt3H, resulted in formation of the corresponding lactone or lactol. In contrast, when an aluminum hydride reagent was used instead of a borohydride reagent, reduction of N-(γ- or δ-oxoacyl)oxazolidinone proceeded unexpectedly to give not the corresponding lactone or lactol, but a tetrahydrofuran or tetrahydropyran derivative, respectively, containing an oxazolidino group.

A new strategy for efficient synthesis of medium and large ring lactones without high dilution or slow addition

We have developed an efficient method for medium and large ring lactone synthesis by a conceptually different ring-expansion strategy. The design of an unprecedented ring conjunction mode of oxetene, combined with the appropriate choice of a Lewis acid promoter and an additive, constitutes the key components of the new process. Enabled by this new approach, the reaction does not require high dilution or slow addition.

Microwave-assisted domino hydroformylation without syngas

Hydroformylation is a powerful reaction that has suffered for some negative prejudices related to the use of gaseous H2 and CO. Now it is possible to carry out hydroformylation and different cyclohydrocarbonylations, even on complex substrates, using aqueous formalin as H2 and CO surrogate in few minutes under microwave irradiation. The catalytic system developed by Morimoto (Rh/BINAP for decomposition of formaldehyde and Rh/Xantphos for hydroformylation) is compatible with microwave dielectric heating and with complex substrates containing ligand atoms allowing rapid domino hydroformylation cyclization reactions without using the external supply of gaseous H2 and CO (gas cylinder) and without any particular safety limitation or device. Georg Thieme Verlag Stuttgart.

Microwave-assisted domino hydroformylation/cyclization reactions: Scope and limitations

Hydroformylation of alkenes can be carried out in short time and with low syngas pressure under microwave (MW) dielectric heating. Alkenes, carrying O-, N-, or C-nucleophilic fragments, can be designed for domino reactions, mainly cyclocondensations. Ally

Chromium-catalyzed homoaldol equivalent reaction employing a nucleophilic propenyl acetate

A scalable, highly regioselective chromium-catalyzed homoaldol equivalent reaction employing 3-bromopropenyl acetate as a masked homoenolate nucleophile in additions to aromatic, aliphatic, and α,β-unsaturated aldehydes under mild Cr/Mn redox conditions in good to excellent yields is reported. The resulting vinyl acetate-containing adducts are easily hydrolyzed with mild base to provide formal homoaldol adducts, or transformed to other more functionalized products by stereoselective transformations including epoxidation and cyclopropanation.

Reductive and brominative termination of alkenol cyclization in aerobic cobalt-catalyzed reactions

(Chemical Equation Presented) Tetrahydrofur-2-ylmethyl radicals were stereoselectively generated from substituted pent-4-en-1-ols in aerobic cobalt(II)-catalyzed oxidations. Intermediates were trapped with cyclohexa -1,4-diene, γ-terpinene, BrCCl3, diethyl dibromomalonate, or electron-deficient olefins such as acrylonitrile or dimethyl fumarate to afford functionalized tetrahydrofurans in synthetically useful yields.