123043-40-3

Upstream product

• 124817-94-3 4-((S)-1-Chloro-pyrrolidin-3-yloxy)-benzonitrile 
• 124817-93-2 (3S)-3-(4-cyanophenoxy)pyrrolidinium trifluoroacetate 
• 124817-91-0 tert-butyl (S)-3-(4-cyanophenoxy)pyrrolidine-1-carboxylate 
• 767-00-0 4-cyanophenol 

Downstream Products

• 124731-71-1 (-)-N-<1-benzoyl-trans-3-(4-cyanophenoxy)-L-prolyl>-L-isoleucine methyl ester 
• 124731-71-1 (+)-N-<1-benzoyl-cis-3-(4-cyanophenoxy)-D-prolyl>-L-isoleucine methyl ester 
• 123043-38-9 N-trans-3-(4-cyanophenoxy)-1-glycyl>-L-prolyl-L-isoleucine methyl ester 

Relevant academic research and scientific papers

Model studies directed toward the total synthesis of 14-membered cyclopeptide alkaloids: Synthesis of prolyl peptides via a four-component condensation

The general applicability of a four-component condensation for the formation of N-acyl-β-aryloxyprolines has been demonstrated in several model studies. The relative stereochemistry of the diastereoisomers obtained has been assigned from 1H n.m.r. studies, and confirmed by an X-ray analysis of one of the stereoisomers.