123044-13-3

Upstream product

• 123044-26-8 2-amino-4-methyl-6-phenyl-6H-1,3-thiazine-5-carboxylic acid ethyl ester hydrochloride 
• 620-80-4 ethyl 2-benzylidene acetoacetate 
• 17356-08-0 thiourea 

Downstream Products

• 123043-88-9 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione 

Relevant academic research and scientific papers

A reexamination of the mechanism of the Biginelli dihydropyrimidine synthesis. Support for an N-acyliminium ion intermediate

The mechanism of three-component Biginelli dihydropyrimidine synthesis was reinvestigated using 1H and 13C NMR spectroscopy. Condensation of benzaldehyde, ethyl acetoacetate, and urea (or N-methylurea) in CD3OH according t

Synthesis and reactions of some pyrimidine derivatives

Three different series of compounds including N-formylated thioxopyrimidines 3a-d, thiazine derivatives 4a-c and N-formylated oxopyrimidines 5a-d were synthesized by reaction of an appropriate ethyl 6-methyl-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-

Combinatorial Synthesis of Functionalized 1,3-Thiazine Libraries Using a Combined Polymer-Supported Reagent/Catch-and-Release Strategy

A dual role: The supported sulfonic acid reagent promotes the ring closure of the thiazine products and also binds them in situ as ion pairs (see scheme). The nonbasic by-products and excess reagents can be removed by filtration and the products subsequen