123064-58-4

Upstream product

• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 105089-88-1 (2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole 
• 75-08-1 ethanethiol 
• 271253-07-7 ethyl N-(2-nitro-5-fluorobenzoyl)pyrrolidine-2-carboxaldehyde 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 455-38-9 3-fluorobenzoic acid 
• 271253-00-0 (S)-1-(5-Fluoro-2-nitro-benzoyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 271253-06-6 N-(2-nitro-5-fluorobenzoyl)pyrrolidine-2-(2-hydroxy)ethane 

Downstream Products

• 123064-62-0 (5-{3-[(3-{3-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-4-nitro-phenylamino}-propyl)-methyl-amino]-propylamino}-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone 
• 123064-60-8 [(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-(5-methoxy-2-nitro-phenyl)-methanone 
• 123064-61-9 [(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-[5-(2-dimethylamino-ethoxy)-2-nitro-phenyl]-methanone 
• 271253-08-8 C₄₃H₅₄N₄O₉S₄ 
• 271253-10-2 C₄₄H₅₆N₄O₉S₄ 
• 271253-09-9 C₄₅H₅₈N₄O₉S₄ 
• 271253-11-3 C₄₆H₆₀N₄O₉S₄ 
• 123064-59-5 [(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-(5-hydroxy-2-nitro-phenyl)-methanone 
• 123085-01-8 (5-{2-[(2-{3-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-4-nitro-phenoxy}-ethyl)-methyl-amino]-ethoxy}-2-nitro-phenyl)-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone 
• 123085-00-7 [5-(6-{3-[(S)-2-(Bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-4-nitro-phenylsulfanyl}-hexylsulfanyl)-2-nitro-phenyl]-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidin-1-yl]-methanone 

Relevant academic research and scientific papers

Design and synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates by the use of SNAr reaction of 2-nitro-5-fluorobenzoate precursor as key reaction

The design and synthesis of a series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates as DNA minor groove binders are described. To introduce polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore, SNA

Synthesis of polyaminoalkyl substituted conjugates of pyrrolo[2,1- c][1,4]benzodiazepine involving S(N)Ar reaction of 2-nitro-5-fluorobenzoate precursors

A synthetic procedure is described for conjugating polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore in order to alter its characteristic DNA sequence binding preference. To this end S(N)Ar reactions of 2-nitro-5-fluorobenzoate

SYNTHESIS AND DNA CROSSLINKING ABILITY OF A DIMERIC ANTHRAMYCIN ANALOG

Linked analogs of the DNA binding antibiotic anthramycin are made via nucleophilic aromatic substitution followed by reduction-cyclization.The linked compounds protect DNA from restriction endonucleases and reversibly crosslink DNA.