271253-10-2

Upstream product

• 123064-58-4 N-(2-nitro-5-fluorobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 261900-39-4 C₂₈H₃₆N₂O₆S₂ 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 53364-99-1 N,N'-ditoluenesulfonyl-1,3-diaminopropane 
• 73276-84-3 N,N′-(propane-1,3-diyl)bis(N-(2-hydroxyethyl)-4-methylbenzenesulfonamide) 
• 98-59-9 p-toluenesulfonyl chloride 
• 271253-07-7 ethyl N-(2-nitro-5-fluorobenzoyl)pyrrolidine-2-carboxaldehyde 
• 271253-06-6 N-(2-nitro-5-fluorobenzoyl)pyrrolidine-2-(2-hydroxy)ethane 
• 271253-00-0 (S)-1-(5-Fluoro-2-nitro-benzoyl)-pyrrolidine-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Design and synthesis of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates by the use of SNAr reaction of 2-nitro-5-fluorobenzoate precursor as key reaction

The design and synthesis of a series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD)- polyaminoalkyl conjugates as DNA minor groove binders are described. To introduce polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore, SNA

Synthesis of polyaminoalkyl substituted conjugates of pyrrolo[2,1- c][1,4]benzodiazepine involving S(N)Ar reaction of 2-nitro-5-fluorobenzoate precursors

A synthetic procedure is described for conjugating polyaminoalkyl groups to the pyrrolo[2,1-c][1,4]benzodiazepine pharmacophore in order to alter its characteristic DNA sequence binding preference. To this end S(N)Ar reactions of 2-nitro-5-fluorobenzoate