123098-55-5Relevant articles and documents
Monosubstituted alkenyl amino acids for peptide "stapling"
Yeo, David J.,Warriner, Stuart L.,Wilson, Andrew J.
supporting information, p. 9131 - 9133 (2013/09/24)
Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.
ASYMMETRIC SYNTHESIS OF α-AMINO ACIDS: COMPARISON OF ENOLATE VS. CATION FUNCTIONALIZATION OF N-BOC-5,6-DIPHENYL-2,3,5,6-TETRAHYDRO-4H-1,4-OXAZIN-2-ONES
Williams, Robert M.,Im, Myeong-Nyeo
, p. 6075 - 6078 (2007/10/02)
Enolate generation and subsequent alkylation of the chiral glycinates 1 and 2 occurs with a high degree of diastereoselectivity.Reduction of the homologation products (3 and 4) furnishes with high enantiomeric excess, the N-t-BOC, and free α-amino acid derivates 5 and 6, respectively.