136707-27-2

Usage

Uses

Used in Pharmaceutical Research:
N-tert-butyloxycarbonyl-C^α-methyl-L-allylglycine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of novel drugs with specific therapeutic properties.
Used in Organic Chemistry:
In the field of organic chemistry, N-tert-butyloxycarbonyl-C^α-methyl-L-allylglycine is utilized as a reagent for the synthesis of complex organic molecules. Its versatility in reactions and the ability to protect the amino group make it an essential component in organic synthesis.
Used in Peptide Synthesis:
N-tert-butyloxycarbonyl-C^α-methyl-L-allylglycine is used as a building block for the assembly of peptides. The Boc protecting group can be easily removed, facilitating the modification and extension of peptide chains, which is crucial for the development of bioactive peptides and peptidomimetics.
Used in the Development of Bioactive Peptides:
N-tert-butyloxycarbonyl-C^α-methyl-L-allylglycine is employed in the creation of bioactive peptides that have potential applications in medicine, such as antimicrobial, antiviral, and anticancer properties. Its unique side chain and protecting group chemistry enable the design of peptides with specific biological activities.
Used in the Synthesis of Peptidomimetics:
N-tert-butyloxycarbonyl-C^α-methyl-L-allylglycine is also used in the synthesis of peptidomimetics, which are compounds that mimic the properties of peptides but are more stable and bioavailable. These peptidomimetics have potential applications in drug discovery and development.

Upstream product

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Relevant academic research and scientific papers

INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION

The present invention relates to Compounds of Formula (I): Formula (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, Ra, Rb, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula (I), and methods of using the compounds of Formula (I) for treating or preventing HIV infection in a subject.

Synthesis, radiolabeling, and biological evaluation of (R)- and (S)-2-amino-5-[18F]fluoro-2-methylpentanoic acid ((R)-, (S)-[18F]FAMPe) as potential positron emission tomography tracers for brain tumors

A novel 18F-labeled α,α-disubstituted amino acid-based tracer, 2-amino-5-[18F]fluoro-2-methylpentanoic acid ([18F]FAMPe), has been developed for brain tumor imaging with a longer alkyl side chain than previously reported c

Stereoselective lodocyclization of (S)-allylalanine derivatives: γ-lactone vs cyclic carbamate formation

An efficient procedure for highly chemo- and stereoselective cyclization of (S)-allylalanine derivatives is reported (diastereomeric ratios up to 96:4) where the reaction course can be completely controlled by switching from γ-lactones to cyclic carbamate

Mag: A Cα-methylated, side-chain unsaturated α-amino acid. Introduction into model peptides and conformational preference

By a chemo-enzymatic approach we synthesized the chiral, C(α)- methylated α-amino acid Mag, characterized by a side-chain C(γ)=C(δ) bond. We also prepared a series of model peptides containing Mag in combination with Aib and Ala. All of the peptides were fully characterized and their conformational preference was determined in solution by FT-IR absorption and 1H NMR investigations. X-Ray diffraction analyses of L-Mag, a derivative and three peptides are also presented. We find that this C(α)-methylated α- amino acid is an excellent β-turn and 310-helix former. A peptide with two Mag residues one on top of the other after one complete turn of the 310- helix has been synthesized and characterized. 2000 Elsevier Science Ltd.