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123126-38-5

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123126-38-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 123126-38-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,1,2 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 123126-38:
(8*1)+(7*2)+(6*3)+(5*1)+(4*2)+(3*6)+(2*3)+(1*8)=85
85 % 10 = 5
So 123126-38-5 is a valid CAS Registry Number.

123126-38-5Relevant articles and documents

Bisfunctionalized Janus molecules

Ropponen, Jarmo,Nummelin, Sami,Rissanen, Kari

, p. 2495 - 2497 (2004)

(Matrix Presented) Bisfunctionalized dendritic multiester molecules were synthesized by combined protection-deprotection and divergent-convergent- divergent sequences in high yields leading to dendritic molecules that combine two functionally different su

Synthesis of flutamide-conjugates

Castillo-Rodríguez, Irving Osiel,Hernández-Ortega, Simón,Martínez-García, Marcos,Martínez-Klimova, Elena,Medina-Rojas, Julio César,Ramírez-ápan, Teresa

, (2020)

In this paper, we designed and extended modification basing on the flutamide structure. A series of flutamide-conjugates were obtained with methyl bromoacetate and ethylenediamine. Through the synthesis of two conjugates with 3,5-bis(dodecyloxy)benzoate derivatives, these flutamide conjugates were tested for anticancer activity. Among the compounds tested, the flutamide-conjugates showed good inhibition activity against cancer cell lines U-251, PC-3 and K-562. The conjugates showed a better inhibitory effect than free flutamide and did not show activity against normal COS-7 monkey kidney fibroblast cells. It was also observed that the flutamide conjugates had an inhibitory effect against human colorectal adenocarcinoma HCT-15.

One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA

Atochina-Vasserman, Elena N.,Billingsley, Margaret M.,Huang, Ning,Kim, Kyunghee,Liu, Matthew,Maurya, Devendra S.,Mitchell, Michael J.,Ni, Houping,Ona, Nathan,Percec, Virgil,Pochan, Darrin J.,Shahnawaz, Hamna,Weissman, Drew,Xiao, Qi,Zhang, Dapeng

, p. 12315 - 12327 (2021/08/20)

Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed for genetic delivery with recent examples being DNA, adenoviral, and mRNA-based Covid-19 vaccines. Viral vectors can be target specific and very efficient but can also mediate severe immune response, cell toxicity, and mutations. Four-component lipid nanoparticles (LNPs) containing ionizable lipids, phospholipids, cholesterol for mechanical properties, and PEG-conjugated lipid for stability represent the current leading nonviral vectors for mRNA. However, the segregation of the neutral ionizable lipid as droplets in the core of the LNP, the "PEG dilemma", and the stability at only very low temperatures limit their efficiency. Here, we report the development of a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement. Six libraries containing 54 sequence-defined IAJDs were synthesized by an accelerated modular-orthogonal methodology and coassembled with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technology often used for LNPs. Forty four (81%) showed activity in vitro and 31 (57%) in vivo. Some, exhibiting organ specificity, are stable at 5 °C and demonstrated higher transfection efficiency than positive control experiments in vitro and in vivo. Aside from practical applications, this proof of concept will help elucidate the mechanisms of packaging and release of mRNA from DNPs as a function of ionizable amine concentration, their sequence, and constitutional isomerism of IAJDs.

Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes

Buzzacchera, Irene,Xiao, Qi,Han, Hong,Rahimi, Khosrow,Li, Shangda,Kostina, Nina Yu.,Toebes, B. Jelle,Wilner, Samantha E.,M?ller, Martin,Rodriguez-Emmenegger, Cesar,Baumgart, Tobias,Wilson, Daniela A.,Wilson, Christopher J.,Klein, Michael L.,Percec, Virgil

, p. 712 - 727 (2018/11/23)

Natural, including plant, and synthetic phenolic acids are employed as building blocks for the synthesis of constitutional isomeric libraries of self-assembling dendrons and dendrimers that are the simplest examples of programmed synthetic macromolecules.

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