1231755-75-1

Basic information

• Product Name: methyl 2-(2-cyanophenyl)acrylate
• Synonyms: methyl 2-(2-cyanophenyl)acrylate
• CAS NO: 1231755-75-1
• Molecular Weight: 187.198
• Mol File: 1231755-75-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-(2-cyanophenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2-cyanophenyl)acrylate(1231755-75-1)
• EPA Substance Registry System: methyl 2-(2-cyanophenyl)acrylate(1231755-75-1)

Safety Data

• Hazardous Substances Data: 1231755-75-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 20921-96-4 methyl 2-(2-cyanophenyl)acetate 

Downstream Products

• 1231755-91-1 methyl (2E)-2-(2-cyanophenyl)-3-(4-methoxycarbonylphenyl)acrylate 
• 1333260-17-5 methyl (E)-3-(2-bromophenyl)-2-(2-cyanophenyl)acrylate 
• 1239316-15-4 4-(4-methoxycarbonylbenzyl)-1,2-dihydroisoquinolin-3-one 
• 1239316-05-2 C₁₉H₁₅NO₄ 
• 1239316-25-6 C₁₉H₁₈F₃NO₃ 
• 1239316-16-5 4-(3-trifluoromethylbenzyl)-1,2-dihydroisoquinolin-3-one 
• 1239316-17-6 4-(3-methoxybenzyl)-1,2-dihydroisoquinolin-3-one 
• 1239316-20-1 4-(2-methylbenzyl)-1,2-dihydroisoquinolin-3-one 

Relevant articles and documents

Room-temperature, ligand- and base-free heck reactions of aryl diazonium salts at low palladium loading: Sustainable preparation of substituted stilbene derivatives

The Pd(OAc)2-catalyzed Heck reaction of aryl diazonium salts with 2-arylacrylates led to cis-stilbenes with good to excellent stereoselectivity. The environmentally friendly protocol developed in this work features low palladium loading in technical-grade methanol at room temperature under base-, additive-, and ligand-free condi-tions. The same protocol applied to simple Heck coupling of aryl diazonium salts with methyl acrylate allows as-tonishingly low palladium loading, down to 0.005 mol %. The stereoselectivity experimentally observed for the synthesis of cis-stilbenes has been rationalized by DFT calculations. Moreover, the role of methanol in promoting the reaction has been clarified by a computational study.