123186-24-3

Usage

Uses

Used in Pharmaceutical Industry:
Benzene, (3-chloro-3-methoxypropyl)is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving existing ones.
Used in Pesticide Production:
Benzene, (3-chloro-3-methoxypropyl)is utilized as an intermediate in the manufacturing process of pesticides, helping to create effective solutions for controlling pests in agriculture and other industries.
Used as a Solvent:
Benzene, (3-chloro-3-methoxypropyl)also serves as a solvent in various chemical processes, aiding in the dissolution and reaction of other substances.
Used in Organic Compound Production:
It is employed as a chemical intermediate in the synthesis of other organic compounds, expanding its applications across different industries.
It is crucial to handle Benzene, (3-chloro-3-methoxypropyl)with care, as it can be harmful if inhaled, ingested, or comes into contact with skin and eyes. Adequate safety measures and precautions should be taken when working with this chemical.

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 30076-98-3 (3,3-dimethoxypropyl)benzene 
• 75-36-5 acetyl chloride 

Downstream Products

• 1101-12-8 Ethyl-(4-nitro-phenyl)-α-methoxy-γ-phenyl-propylphosphonat 
• 151562-88-8 1,8-dihydroxy-10-(1-methoxy-3-phenylpropyl)-9(10H)-antharacenone 
• 114262-84-9 (3-methoxypent-1-yne-1,5-diyl)dibenzene 
• 127333-75-9 2-(1-methoxy-3-phenylpropoxy)-6-(phenylthio)-6-heptene 
• 123185-97-7 4-chloro-2-(2-phenylethyl)-2,3,4,5,6,7-hexahydrooxepin 
• 123186-01-6 2-(2-phenylethyl)-2,3,4,5,6,7-hexahydrooxepin 
• 123185-99-9 5-chloro-2-(2-phenylethyl)-2,3,4,5,6,7-hexahydrooxepin 
• 153942-89-3 (1-methoxy-3-phenylpropyl)tributylstannane 
• 127333-77-1 cis-8-methyl-2-(2-phenylethyl)-4-(phenylthio)-3,6,7,8-tetrahydro-2H-oxocin 
• 127333-78-2 8-methyl-2-(2-phenylethyl)-3,6,7,8-tetrahydro-2H-oxocin 
• 123185-96-6 5-((1-methoxy-3-phenyl)propoxy)-1-pentene 

Relevant academic research and scientific papers

The catalytic asymmetric acetalization

In straitened circumstances: In an asymmetric version of the acid-catalyzed acetalization of aldehydes, a novel member of the chiral confined Bronsted acid family significantly outperformed previously established catalysts, providing cyclic acetals with e

Stereospecific palladium/copper cocatalyzed cross-coupling of α-alkoxy- and α-aminostannanes with acyl chlorides

Stille-type cross-coupling between α-alkoxy(amino)stannanes and acyl chlorides affords α-hetero-substituted ketones in moderate to good yields when cocatalyzed by Pd and Cu(I) salts. The reaction is applicable to a wide range of tin compounds, especially those bearing α-electron-withdrawing groups such as benzoyloxy or acetyloxy, although some ethers (e.g., MOM) are also satisfactory. Aromatic acid chlorides give the best yields. Coupling of chiral α-alkoxystannanes, readily available by BINAL-H asymmetric reduction of acylstannanes, proceeds with retention of configuration.

Antipsoriatic Anthrones with Modulated Redox Properties. 1. Novel 10-Substituted 1,8-Dihydroxy-9(10H)-anthracenones as Inhibitors of 5-Lipoxygenase

The syntheses, the biological evaluation, and the structure-activity relationships of a novel series of 1,8-dihydroxy-9(10H)-anthracenones bearing acyl-, alkyl-, or alkylidene-linked aromatic substituents in the 10-position are described.The phenylacyl and phenylalkylidene analogs were far more potent inhibitors of 5-lipoxygenase (5-LO) from bovine polymorphonuclear leukocytes (IC50 values in the 10-7 M range) than the antipsoriatic drug anthralin, whereas phenylalkyl analogs were only weak inhibitors.Among the active compounds were both potent generators of hydroxyl radicals, as determined by deoxyribose degradation, and strong reducers of the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH).However, several derivatives of this series maintained 5-LO inhibitory activity but did not generate hydroxyl radicals and were not reactive with DPPH.In particular, phenylacyl analogs were also 6 times more efficient in inhibition of lipid peroxidation in model membranes than anthralin.Structure-activity relationships have shown that the presence of free phenolic groups in the attached aromatic ring is beneficial but not required for 5-LO inhibitory potency.The inhibitory potency in the 10-phenylacyl series increased with the length of the acyl chain with three methylene units being the optimum, suggesting a specific enzyme interaction which would not be expected for nonspecific redox inhibitors.