123194-05-8

Basic information

• Product Name: Cyclohexanemethanamine, 1-amino-, dihydrochloride
• CAS NO: 123194-05-8
• Molecular Formula: C7H16N2.2ClH
• Molecular Weight: 201.139
• Mol File: 123194-05-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclohexanemethanamine, 1-amino-, dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanemethanamine, 1-amino-, dihydrochloride(123194-05-8)
• EPA Substance Registry System: Cyclohexanemethanamine, 1-amino-, dihydrochloride(123194-05-8)

Safety Data

• Hazardous Substances Data: 123194-05-8(Hazardous Substances Data)

Upstream product

• 143-33-9 sodium cyanide 
• 108-94-1 cyclohexanone 
• 1258951-62-0 1-azido-1-(nitromethyl)cyclohexane 
• 5496-10-6 1-amino-1-cyanocyclohexane 

Downstream Products

• 5062-67-9 1-amino-1-aminomethyl-cyclohexane 
• 13157-24-9 1,3-diazaspiro[4.5]decane-2-thione 
• 1221349-45-6 2-(1,3-diazaspiro[4.5]-dec-2-en-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-benzimidazole 
• 879514-41-7 N-[(1-aminocyclohexyl)methyl]-3-nitroquinolin-4-amine 

Relevant articles and documents

Preparation method of 1, 4-diazaspiro[5, 5]undecane-3-one

The invention discloses a preparation method of 1, 4-diazaspiro[5, 5]undecane -3-one, and belongs to the technical field of medical intermediates. Cyclohexanone is used as a raw material and reacts with nitromethane in ammonia water to obtain 1-nitromethylcyclohexylamine; then excessive hydrochloric acid is added, and palladium/carbon catalytic hydrogenation is performed in an alcohol solvent to obtain 1-aminomethylcyclohexylamine dihydrochloride; and then an inorganic alkali is added for dissociation, and the obtained substance reacts with halogen acetyl halide/halogen acetate to obtain 1, 4-diazaspiro[5, 5]undecane-3-one. The synthesis method has the advantages of few reaction steps, continuous operation and easily available raw materials, the HPLC purity of the obtained product is greater than 99.0%, and the synthesis method has a potential industrial amplification prospect.

A practical synthesis of 1,2-nitroamines by Michael addition of N-nucleophiles to nitroalkenes

A practical method for the synthesis of-nitroamines by Michael addition of azide to nitroalkene has been developed. This reaction proceeds in high yields under very mild conditions (phase-transfer catalysis) and is found to be general; good yields are obtained with both aryl and alkyl derivatives as well as with 1,1-di-substituted ones. Georg Thieme Verlag Stuttgart - New York.

DIPEPTIDYL PEPTIDASE IV INHIBITOR

A compound represented by general formula (I):A-B-D whereinA represents a substituted or unsubstituted 1-pyrrolidinyl group, a substituted or unsubstituted 3-thiazolidinyl group, a substituted or unsubstituted 1-oxo-3-thiazolidinyl group, or the like;B r