5496-10-6

Usage

Uses

Used in Pharmaceutical Industry:
1-amino-1-cyanocyclohexane is used as a building block for the production of pharmaceuticals due to its ability to be incorporated into various drug molecules, contributing to the development of new medications.
Used in Agrochemical Industry:
1-amino-1-cyanocyclohexane is used as a building block for the production of agrochemicals, playing a role in the synthesis of compounds that help protect crops and enhance agricultural productivity.
Used in Fine Chemicals Industry:
1-amino-1-cyanocyclohexane is used as a building block for the production of fine chemicals, which are important in various specialized applications such as fragrances, dyes, and other high-value chemical products.
Used as a Stabilizer in Ethyleneamine Synthesis:
1-amino-1-cyanocyclohexane is used as a stabilizer in the synthesis of ethyleneamines, helping to improve the stability and quality of the final product.
Used as a Reagent in Heterocyclic Compound Preparation:
1-amino-1-cyanocyclohexane is used as a reagent in the preparation of various heterocyclic compounds, which are important in the synthesis of complex organic molecules and have applications in various industries.
Used as a Ligand in Coordination Chemistry:
1-amino-1-cyanocyclohexane can be used as a ligand in coordination chemistry, playing a role in the formation of coordination compounds that have applications in catalysis, materials science, and other areas.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
1-amino-1-cyanocyclohexane can be used as a chiral auxiliary in asymmetric synthesis, helping to control the stereochemistry of reactions and produce enantiomerically pure compounds, which are important in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C7H12N2/c8-6-7(9)4-2-1-3-5-7/h1-5,9H2/p+1

Upstream product

• 931-97-5 1-hydroxy-1-cyclohexanecarbonitrile 
• 17643-01-5 1,2-di-1-(1-cyano)-cyclohexylhydrazine 
• 74-90-8 hydrogen cyanide 
• 108-94-1 cyclohexanone 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 
• 7664-41-7 ammonia 
• 7732-18-5 water 
• 7677-24-9 trimethylsilyl cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 773837-37-9 sodium cyanide 
• 1855-63-6 cyclohex-1-enecarbonitrile 

Downstream Products

• 4550-68-9 1-acetamidocyclohexanecarbonitrile 
• 92255-24-8 1-Benzoylamino-cyclohexylnitril 
• 100957-36-6 1-(2-phenyl-acetylamino)-cyclohexanecarbonitrile 
• 702-62-5 spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione 
• 2756-85-6 1-aminocyclohexane carboxylic acid 
• 41556-40-5 1,1'-imino-bis-cyclohexanecarbonitrile 
• 85599-83-3 1--1-cyclohexene 
• 99379-44-9 5-(4-nitrophenylamino)-2-(4-nitrophenyl)-4,4-pentamethylene-4H-imidazole 
• 2582-16-3 2,2,5,5-tetramethylimidazolidine-4-thione 
• 15051-76-0 cyclohexanespiro-5'-(2',2'-dimethylimidazolidin-4'-thione) 
• 4833-50-5 cyclohexanespiro-2'-(imidazolidin-4'-thione)-5'-spirocyclohexane 
• 17324-90-2 1-aminocyclohexane-1-carboxamide 
• 1125-02-6 1-cyano-1-formamidocyclohexane 
• 4854-57-3 1-acetamidocyclohexanecarboxamide 

Relevant academic research and scientific papers

Photoreactive fused aziridinylpiperazines on the background of 4-substituted chalcones and their benzimidazolic analogs

The reaction of bromo-substituted chalcones with various diamino-compounds leads to the fused heterocyclic products, aziridinylpiperazines, exhibiting photoreactivity in the crystalline state. Crystals of 4-nitrosubstituted compounds of this family change their color from yellowish to deep violet-blue, 4-cyanosubstituted ones – from yellowish to pink at UV irradiation. Discussion on the mechanism of this phototransformation is still in progress, however, several facts points to the free radial nature of the photogenerated colored semi-products stabilized only by crystalline state of the irradiated samples. Formation of a mixture of positional isomers at interaction of bromo-chalcones with asymmetric diamines of aliphatic/alicyclic or aromatic series at synthesis of the title compounds is of significant interest as well.

Synthesis of: N -unsubstituted cycloalkylimines containing a 4 to 8-membered ring

Primary cycloalkylimines with a 4 to 8-membered ring were synthesized by dehydrocyanation of the corresponding α-aminonitriles on solid potassium hydroxide via a vacuum gas-solid reaction. Imine-enamine tautomerism has been demonstrated at room temperature for the most kinetically stable derivatives.

SYNTHESIS OF N-(HETEROARYL)-PYRROLO[3,2-D]PYRIMIDIN-2-AMINES

This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

Design and synthesis of certain substituted cycloalkanecarboxamides structurally related to safinamide with anticonvulsant potential

A series of novel safinamide derivatives were synthesized and biologically evaluated for their anticonvulsant activity against maximal electroshock seizure assay and subcutaneous pentylenetetrazole (s.c. PTZ) screening test. Compound 13b is the most active derivative in s.c. PTZ screening test with an ED50 value lower than that of safinamide by about tenfold. A molecular modeling study, including fitting to sodium channel blockers 3D-pharmacophore model and docking into a branched-chain aminotransferase enzyme active site were consistent with the in vivo results.

Transamination of a-amino nitriles

α-Amino nitriles containing a primary amino group undergo transamination with aliphatic and aromatic amines under mild conditions with high yields. A probable reaction mechanism involving intermediate elimination of cyanide ion has been proposed.

Approaches to the construction of substituted 4-amino-1 H -pyrrol-2(5 H)-ones

Fully substituted 4-aminopyrrolones are easily accessed via simple routes starting from imines, ketones, or α-bromophenyl acetonitriles. Imines were reacted with KCN/NH4Cl in aqueous ethanol to produce α-arylamino benzyl cyanides. On the other hand, ketones were transformed to the desired α-amino nitriles using a modified Strecker reaction. Then, α-amino nitrile precursors were allowed to react with a suitable acyl halide to produce the corresponding amides. Further treatment of these amides with ethanolic KOH converted them to highly substituted 4-amino-1H-pyrrol-2(5H)- one derivatives in moderate to excellent yields.

Versatile synthesis of free and N-benzyloxycarbonyl-protected 2,2-disubstituted taurines

An effective and versatile method was developed to synthesize N-benzyloxycarbonyl-protected and free 2,2-disubstituted taurines. Several novel 2,2-disubstituted taurines, including aliphatic/aromatic and cyclic/acyclic derivatives, were obtained, which demonstrates the generality of this method. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

NEW GALLIUM BISAMINOTHIOLATE COMPLEXES FOR MYOCARDIAL IMAGING

The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts thereof; wherein A1, A2 and A3 are the same or different cycloalkyl, wherein at least one of A1, A2 or A3 is substituted. R1 through R6 are independently hydrogen or alkyl, R7 and R8 are independently hydrogen or alkyl and RP is hydrogen or sulfhydryl protecting group. This invention is also directed to complexes, wherein said compounds chelate radioactive metal ions, such as Gallium. The complexes of the rpesent invention are useful as myocardial perfusion imaging agents.

Total syntheses of (±)-massadine and massadine chloride

The total syntheses of the complex pyrrole-imidazole alkaloids (±)-massadine and (±)-massadine chloride is described using a carefully orchestrated sequence of manipulations on highly polar and structurally complex intermediates. Key to the completion of this synthetic endeavor was the exploration of a unique and chemoselective method to oxidize unprotected guanidines under aqueous conditions in air. This oxidation has been optimized and applied to a selection of spirocyclic guanidines of varying complexity. Additionally, the 3,7-epi analogues of these interesting natural products have been synthesized and fully characterized. Copyright

Methods and compositions for treating amyloid-related diseases

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.