1231980-45-2Relevant academic research and scientific papers
Thiadiazole-based Thioglycosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors
Gao, Yunlong,Zhao, Guilong,Liu, Wei,Wang, Yuli,Xu, Weiren,Wang, Jianwu
experimental part, p. 605 - 612 (2010/10/19)
A series of thiadiazole-based thioglycosides were synthesized as SGLT2 inhibitors from D-glucose, D-galactose and a variety of phenylacetic acids via a convenient protocol in 8 steps and evaluated in vivo with an oral glucose tolerance test (OGTT), and 5-benzyl-1,3,4-thiadiazol-2-yl 1-thio-β-D-glucopyranoside (1a) was the most efficacious to suppress the blood glucose excursion during OGTT.
