1232148-22-9

Basic information

• Product Name: 2-(4-fluorophenyl)-6-oxo-6-(2-oxo-4(S)-phenyloxazolidin-3-yl)-2-trimethylsilyloxyhexanenitrile
• Synonyms: 2-(4-fluorophenyl)-6-oxo-6-(2-oxo-4(S)-phenyloxazolidin-3-yl)-2-trimethylsilyloxyhexanenitrile
• CAS NO: 1232148-22-9
• Molecular Weight: 454.573
• Mol File: 1232148-22-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-6-oxo-6-(2-oxo-4(S)-phenyloxazolidin-3-yl)-2-trimethylsilyloxyhexanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-6-oxo-6-(2-oxo-4(S)-phenyloxazolidin-3-yl)-2-trimethylsilyloxyhexanenitrile(1232148-22-9)
• EPA Substance Registry System: 2-(4-fluorophenyl)-6-oxo-6-(2-oxo-4(S)-phenyloxazolidin-3-yl)-2-trimethylsilyloxyhexanenitrile(1232148-22-9)

Safety Data

• Hazardous Substances Data: 1232148-22-9(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 189028-93-1 (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione 

Downstream Products

• 1232148-24-1 2,2-dimethylpropionic acid 4-[(1S,2R)-5-cyano-5-(4-fluorophenyl)-1-(4-fluorophenylamino)-2-(2-oxo-4(S)-phenyloxazolidine-3-carbonyl)-5-trimethylsilyloxypentyl]phenyl ester 

Relevant articles and documents

METHOD OF PREPARING EZETIMIBE AND INTERMEDIATES USED THEREIN

Disclosed is a method for preparing ezetimibe which is effective for preventing or treating arteriosclerosis, and novel intermediates used therein. In accordance with the method which does not use expensive reagents, unwanted diastereoisomers can be easily removed by a step-by-step crystallization procedure, and the ezetimibe of formula 1 can be prepared in a high yield without the use of a hydrogenation procedure under a high pressure.