1232149-46-0

Upstream product

• 1232148-36-5 7-bromo-2-(2-chloro-6-fluorophenyl)imidazo[4,5-c]quinoline 
• 1232149-37-9 7-bromo-3,4-diaminoquinoline 
• 387-45-1 2-chloro-6-fluorobenzaldehyde 

Downstream Products

• 1436688-58-2 2-(2-chloro-6-fluorophenyl)-7-(2-methylphenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1436688-61-7 2-(2-chloro-6-fluorophenyl)-7-(3-methylphenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1436688-64-0 2-(2-chloro-6-fluorophenyl)-7-(4-methylphenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1436688-67-3 2-(2-chloro-6-fluorophenyl)-7-(2-chlorophenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1436688-73-1 2-(2-chloro-6-fluorophenyl)-7-(4-chlorophenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1232148-53-6 7-bromo-4-chloro-2-(2-chloro-6-fluorophenyl)imidazo[4,5-c]quinoline 
• 1232149-28-8 7-bromo-2-(2-chloro-6-fluorophenyl)imidazo[4,5-c]quinolin-4(5H)-one 
• 1436688-70-8 2-(2-chloro-6-fluorophenyl)-7-(3-chlorophenyl)imidazo[4,5-c]quinolin-4(5H)-one 

Relevant academic research and scientific papers

7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors

To identify compounds with strong mPGES-1 inhibitory activity and clear in vitro ADME profile, we optimized the lead compound 1 by carrying our substitutions at the C(7)- and C(8)-positions. Replacement of the bromine atom of 1 with various substituents l