123217-59-4

Upstream product

• 123217-62-9 2-(4-chloro-phenyl)-3-hydroxy-3-methyl-2,3-dihydro-isoindol-1-one 
• 313268-48-3 2-iodo-N-(4-chlorophenyl)benzamide 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 28269-50-3 2-vinylbenzoic acid chloride 
• 27326-43-8 2-vinylbenzoic acid 
• 119-67-5 o-carboxybenzaldehyde 
• 577-56-0 2-acetyl-benzoic acid 
• 106-47-8 4-chloro-aniline 
• 201230-82-2 carbon monoxide 
• 25287-19-8 N-(1-phenylethylidene)-4-chloroaniline 

Relevant academic research and scientific papers

Synthesis of 3-methyleneisoindolin-1-ones via palladium-catalyzed C-Cl bond cleavage and cyclocarbonylation of ortho-chloro ketimines

PdCl2(PCy3)2-catalyzed cyclocarbonylative coupling of ortho-chloro arylketimines with CO has been investigated to develop an efficient method for the synthesis of isoindolin-1-ones. The developed synthetic method has the a

Synthesis of 3-Alkylideneisoindolin-1-ones via Sonogashira Cyclocarbonylative Reactions of 2-Ethynylbenzamides

Cyclocarbonylative Sonogashira reactions of ortho-ethynylbenzamides have been investigated. The process is carried out under CO pressure, in the presence of a very small amount of PdCl2(PPh3)2 (0.4 mol %) as a catalytic precursor and without the need for

Synthesis of Isoindolinones through Intramolecular Amidation of ortho-Vinyl Benzamides

A synthetic approach of isoindolinones through intramolecular amidation of ortho-vinyl benzamides was reported. A variety of N-aryl isoindolinone derivatives were prepared in moderate to excellent yields using perfluorobutyl iodide as oxidant. (Figure pre

A Sulfone-Containing Imidazolium-Based Br?nsted Acid Ionic Liquid Catalyst Enables Replacing Dipolar Aprotic Solvents with Butyl Acetate

Replacing dipolar and aprotic solvents with environmentally benign media has emerged as a new facet of green chemistry. In this paper, a sulfone-containing imidazolium-based Br?nsted acid ionic liquid was prepared and used as a recyclable acid catalyst. The ionic liquid catalyst enables the use of an industrially acceptable and environmentally benign solvent, butyl acetate, as the reaction medium. The ionic liquid/butyl acetate biphasic system was successfully utilized in many organic reactions, which generally relied heavily on dipolar and aprotic solvents. (Figure presented.).

Rhodium-Catalyzed Cyclocarbonylation of Ketimines via C-H Bond Activation

A novel rhodium-catalyzed oxidative cyclocarbonylation of ketimines via cleavage of two C-H bonds was established, which provided a direct and reliable method for the synthesis of a wide range of 3-methyleneisoindolin-1-ones with mostly moderate yields. P

Reaction of 3-Hydroxyisoindolin-1-ones with Lawesson Reagent. Synthesis of Isoindoline-1-thiones

Treatment of 3-hydroxyisoindolin-1-ones 1 with Lawesson reagent gave isoindoline-1-thiones 2, by direct thionation and reductive elimination of hydroxy group, in good yields.