123228-00-2

Upstream product

• 114953-71-8 [(1-chloro-2,2,2-trifluoroethyl)sulfanyl]benzene 
• 71-43-2 benzene 
• 108200-49-3 Phenyl 1-methoxy-2,2,2-trifluoroethyl sulfide 
• 108-98-5 thiophenol 
• 185424-21-9 Methanesulfonic acid 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 2262-07-9 2,2,2-trifluoroethyl phenyl sulfide 
• 340-04-5 1-phenyl-2,2,2-trifluoromethylethanol 

Downstream Products

• 1402748-54-2 (2,2,2-trifluoro-1-phenylethylsulfonyl)benzene 
• 1402748-65-5 (1,1,1-trifluoro-2-phenylpent-4-en-2-ylsulfonyl)benzene 

Relevant academic research and scientific papers

Functional group transformation of α-trifluoromethylated alcohol derivatives

Functional group transformation of α-trifluoromethylated alcohols was investigated. Nucleophilic substitutions of their sulfonates was achieved in the presence of metal fluoride as a base with complete inversion of the configuration.

Efficient Synthesis of Novel α-Aryl(alkyl)-β,β-difluorovinyl and α-Aryl(alkyl)-β-fluoro-β-perfluoroalkylvinyl Sulfides

Reaction of 1,1-bis(phenylthio)perfluoroalkyl aromatics or alkanes with a mixture of 2 equiv. of TiCl4 and 4 equiv. of LiAlH4 in THF at reflux temperature for 3 hours afforded α-aryl(alkyl)-β,β-difluorovinyl and α-aryl(alkyl)-β-fluoro-β-perfluoroalkylviny

Electrolytic Reactions of Fluoro Organic Compounds. 7. Anodic Methoxylation and Acetoxylation of 2,2,2-Trifluoroethyl Sulfides. Preparation of Highly Useful Trifluoromethylated Building Blocks

Anodic methoxylation and acetoxylation of 2,2,2-trifluoroethyl sulfides and the corresponding nonfluorinated sulfides were comparatively studied.It was found that a trifluoromethyl group remarkably promoted anodic substitution and methoxy and acetoxy groups were introduced adjacent to the trifluoromethyl group of the sulfides.Longer perfluoroalkyl groups also promoted these anodic substitutions.These products were shown to be highly useful building blocks fro the synthesis of fluoro organic compounds.

Generation and Electrophilic Reactions of the 2,2,2-Trifluoro-1-(phenylthio)ethyl Carbocation

2,2,2-Trifluoro-1-(phenylthio)ethyl carbocation (4) has been generated by the reaction of 1-chloro-2,2,2-trifluoroethyl phenyl sulfide (7b) with ZnCl2 in nitromethane or SnCl4 in 1,2-dichloroethane.The carbocation 4 can be trapped with various aromatics b

GENERATION AND REACTION OF 2,2,2-TRIFLUORO-1-PHENYLSULFENYLETHYL CARBOCATION

Lewis acid-catalyzed dechlorination of 1-chloro-2,2,2-trifluoroethyl phenyl sulfide generates 2,2,2-trifluoro-1-phenylsulfenylethyl carbocation which undergoes electrophilic reaction with aromatic compounds.