Cas 1232335-52-2,1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]-N-isobutyl-cyclopropanecarboxamide

1232335-52-2

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Basic information

Product Name: 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]-N-isobutyl-cyclopropanecarboxamide
Synonyms:
CAS NO:1232335-52-2
Molecular Formula:
Molecular Weight: 389.457
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]-N-isobutyl-cyclopropanecarboxamide(CAS DataBase Reference)
NIST Chemistry Reference: 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]-N-isobutyl-cyclopropanecarboxamide(1232335-52-2)
EPA Substance Registry System: 1-[5-(3-cyanophenyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-yl]-N-isobutyl-cyclopropanecarboxamide(1232335-52-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1232335-52-2(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1232335-52-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,2,3,3 and 5 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1232335-52:
(9*1)+(8*2)+(7*3)+(6*2)+(5*3)+(4*3)+(3*5)+(2*5)+(1*2)=112
112 % 10 = 2
So 1232335-52-2 is a valid CAS Registry Number.

1232335-52-2Upstream product

1232335-52-2Downstream Products

1232335-52-2Relevant academic research and scientific papers

Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3 H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5- a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel "dual-Soft" PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis

Larsen, Jens,Lambert, Maja,Pettersson, Henrik,Vifian, Thomas,Larsen, Mogens,Ollerstam, Anna,Hegardt, Pontus,Eskilsson, Cecilia,Laursen, Steen,Soehoel, Anders,Skak-Nielsen, Tine,Hansen, Lene M.,Knudsen, Nina ?.,Eirefelt, Stefan,S?rensen, Morten D.,Stilou, Tatiana G.,Nielsen, Simon F.

, p. 14502 - 14521 (2020)

We describe the design of a novel PDE4 scaffold and the exploration of the dual-soft concept to reduce systemic side effects via rapid elimination: introducing ester functionalities that can be inactivated in blood as well as by the liver (dual-soft) while being stable in human skin. Compound 40 was selected as a clinical candidate as it was potent and rapidly degraded by blood and liver to inactive metabolites and because in preclinical studies it showed high exposure at the target organ: the skin. Preclinical and clinical data are presented confirming the value of the dual-soft concept in reducing systemic exposure.

TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF DERMAL DISEASES

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Page/Page column 128, (2010/08/05)

The present invention relates to a compound according to formula I, wherein R1, R2 and A are as defined herein, which exhibit PDE4 inhibitory activity and may be used in the treatment of inflammatory diseases or autoimmune diseases,

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